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PA1-31216 detects BMP8 from rat, mouse, human samples.
BMP-8B encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic cancer. BMP-8B may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BMP; BMP-8; BMP-8B; Bone morphogenetic protein; bone morphogenetic protein 8 (osteogenic protein 2); Bone morphogenetic protein 8B; dJ118J21.1 (bone morphogenetic protein 8 (osteogenic protein 2)); MGC131757; OP-2; Osteogenic protein 2
基因别名: BMP8; BMP8B; OP2; Op3
UniProt ID: (Human) P34820, (Mouse) P55105
Entrez Gene ID: (Human) 656, (Mouse) 12164, (Rat) 679119