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BMP2 Antibody (BS-0514R) in WB
Lane 1:U2os cell lysates; Lane 2: MG63 cell lysates; Lane 3: Huvec cell lysates; Lane 4: Hela cell lysates probed with BMP2 Polyclonal Antibody, Unconjugated (bs-0514R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
产品信息
BS-0514R
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant human BMP2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 1% BSA, 50% glycerol
内含物
0.03% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Bone Morphogenic Proteins (BMP) are members of the TGF-beta superfamily that affect bone and cartilage formation (Hogan 1996, Reddi 1998 and Francis-West et al. 1999). Mature BMPs are 30-38 kDa proteins that assume a TGF-beta -like cysteine knot configuration. Lovostatin increases bone formation by turning on the bmp-2 gene (Mundy et al. 1999). BMPs stimulate the production of specific bone matrix proteins and alter stromal cell and osteoclast proliferation (Macias et al. 1999, Lecanda et al. 1997). BMPs may also be an important factor for development of the viscera, with roles in cell proliferation, apoptosis, differentiation, and morphogenesis (Hogan 1996, Dale and Wardle 1999). BMPs appear to be responsible for normal dorsal/ventral patterning. Like TGF-beta, BMPs bind to a type II receptor, which then recruits the transducing type I receptor unit, activating the Smad protein signaling pathway (Massague 1994, Derynck 1997, Attisano 1993).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2610024H22Rik; AL117858; AW546137; BB189135; BMP; BMP-2; BMP-2A; BMPR-II; BMPRII; Bone morphogenetic protein; Bone morphogenetic protein 2; Bone morphogenetic protein 2A; H-BMP-2
基因别名: BDA2; BMP2; BMP2A
UniProt ID: (Human) P12643
Entrez Gene ID: (Human) 650
negative regulation of transcription from RNA polymerase II promoter
activation of MAPK activity
skeletal system development
osteoblast differentiation
branching involved in ureteric bud morphogenesis
response to hypoxia
in utero embryonic development
epithelial to mesenchymal transition
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
chondrocyte differentiation
BMP signaling pathway involved in heart induction
atrioventricular valve morphogenesis
endocardial cushion morphogenesis
negative regulation of Wnt signaling pathway involved in heart development
proteoglycan metabolic process
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
Notch signaling pathway
cell-cell signaling
heart development
negative regulation of cell proliferation
embryo development
organ morphogenesis
positive regulation of gene expression
positive regulation of epithelial to mesenchymal transition
positive regulation of pathway-restricted SMAD protein phosphorylation
negative regulation of steroid biosynthetic process
positive regulation of phosphatase activity
telencephalon development
telencephalon regionalization
positive regulation of Wnt signaling pathway
bone mineralization
positive regulation of cell migration
positive regulation of bone mineralization
BMP signaling pathway
protein destabilization
positive regulation of protein binding
negative regulation of aldosterone biosynthetic process
positive regulation of osteoblast proliferation
cardiocyte differentiation
embryonic heart tube anterior/posterior pattern specification
bone mineralization involved in bone maturation
growth
odontogenesis of dentin-containing tooth
positive regulation of odontogenesis
regulation of odontogenesis of dentin-containing tooth
positive regulation of apoptotic process
positive regulation of MAPK cascade
negative regulation of insulin-like growth factor receptor signaling pathway
cell fate commitment
positive regulation of fat cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of ossification
negative regulation of cell cycle
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of astrocyte differentiation
mesenchymal cell differentiation
inner ear development
negative regulation of calcium-independent cell-cell adhesion
cardiac muscle cell differentiation
cardiac muscle tissue morphogenesis
oxidation-reduction process
pericardium development
corticotropin hormone secreting cell differentiation
thyroid-stimulating hormone-secreting cell differentiation
cardiac epithelial to mesenchymal transition
pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
mesenchyme development
positive regulation of Wnt signaling pathway by BMP signaling pathway
positive regulation of cartilage development
positive regulation of ERK1 and ERK2 cascade
cellular response to organic cyclic compound
cellular response to BMP stimulus
mesenchymal cell proliferation involved in ureteric bud development
negative regulation of canonical Wnt signaling pathway
positive regulation of p38MAPK cascade
positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
negative regulation of cortisol biosynthetic process
negative regulation of cardiac muscle cell differentiation
