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Sequence of this protein is as follows: NQNRNKSSSH QDSSRMSSVG DYNTSEQKQA CKKHELYVSF RDLGWQDWII APEGYAAFYC DGECSFPLNA HMNATNHAIV QTLVHLMFPD HVPKPCCAPT KLNAISVLYF DDSSNVILKK YRNMVVRSCG CH
RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: BMP; BMP 5; BMP-5; bone morphogenenic protein-5; Bone morphogenetic protein; Bone morphogenetic protein 5; MGC34244
基因别名: BMP5
UniProt ID: (Human) P22003
Entrez Gene ID: (Human) 653