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产品信息
PA5-78879
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human BMP6 (383-419aa QSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYV).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 5mg BSA
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2745995
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
BMP6 is a member of bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BMP; BMP 6; BMP-6; Bone morphogenetic protein; Bone morphogenetic protein 6; vegetal related growth factor (TGFB-related); vegetal-related (TGFB related) cytokine; VG-1-R; VG-1-related protein; Vg1-related sequence; VGR-1
基因别名: BMP6; VGR; VGR1
UniProt ID: (Human) P22004
Entrez Gene ID: (Human) 654
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast differentiation
eye development
kidney development
positive regulation of endothelial cell proliferation
endochondral ossification
type B pancreatic cell development
cellular iron ion homeostasis
inflammatory response
immune response
positive regulation of pathway-restricted SMAD protein phosphorylation
response to activity
positive regulation of bone mineralization
BMP signaling pathway
male genitalia development
positive regulation of lipopolysaccharide-mediated signaling pathway
response to magnesium ion
positive regulation of chondrocyte differentiation
positive regulation of aldosterone biosynthetic process
response to retinoic acid
growth
regulation of apoptotic process
regulation of MAPK cascade
positive regulation of endothelial cell differentiation
positive regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
positive regulation of epithelial cell proliferation
positive regulation of protein secretion
cartilage development
response to glucocorticoid
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
multicellular organismal iron ion homeostasis
cellular response to mechanical stimulus
cellular response to iron ion
cellular response to BMP stimulus
positive regulation of DNA-dependent DNA replication
positive regulation of aldosterone secretion
