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产品信息
PA5-11856
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 21-51 amino acids from the N-terminal region of human BMPR1A
偶联物
形式
Liquid
浓度
2 mg/mL
纯化类型
Ammonium sulfate precipitation, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10983970
靶标信息
BMPR1A is a Type I member of the TGF beta receptor superfamily of transmembrane ser/thr kinases which phosphorylates intracellular SMADs in response to bone morphogenic proteins. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: activin A receptor, type II-like kinase 3; Activin receptor-like kinase 3; ALK-3; BMP type-1A receptor; BMPR-1A; BMPRIA; bone morphogenetic protein receptor type IA; Bone morphogenetic protein receptor type-1A; bone morphogenetic protein receptor, type IA; CD292; Serine/threonine-protein kinase receptor R5; SKR5
基因别名: 10q23del; ACVRLK3; ALK3; BMPR1A; CD292; SKR5
UniProt ID: (Human) P36894
Entrez Gene ID: (Human) 657
RNA polymerase II transcription factor activity, sequence-specific DNA binding
glycoprotein binding
protein serine/threonine kinase activity
transmembrane receptor protein serine/threonine kinase activity
receptor signaling protein serine/threonine kinase activity
protein binding
ATP binding
protein homodimerization activity
SMAD binding
metal ion binding
BMP receptor activity
serine/threonine protein kinase receptor
in utero embryonic development
mesoderm formation
somitogenesis
Mullerian duct regression
positive regulation of mesenchymal cell proliferation
chondrocyte differentiation
outflow tract septum morphogenesis
outflow tract morphogenesis
cardiac conduction system development
mitral valve morphogenesis
tricuspid valve morphogenesis
endocardial cushion morphogenesis
cardiac right ventricle morphogenesis
ventricular trabecula myocardium morphogenesis
ventricular compact myocardium morphogenesis
endocardial cushion formation
protein phosphorylation
immune response
transforming growth factor beta receptor signaling pathway
ectoderm development
dorsal/ventral axis specification
regulation of cardiac muscle cell apoptotic process
positive regulation of pathway-restricted SMAD protein phosphorylation
neural crest cell development
negative regulation of smooth muscle cell migration
stem cell population maintenance
pituitary gland development
neural plate mediolateral regionalization
signal transduction by protein phosphorylation
lung development
positive regulation of bone mineralization
BMP signaling pathway
hindlimb morphogenesis
dorsal aorta morphogenesis
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
positive regulation of osteoblast differentiation
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm structural organization
lateral mesoderm development
regulation of lateral mesodermal cell fate specification
mesendoderm development
embryonic organ development
developmental growth
positive regulation of epithelial cell proliferation
negative regulation of neurogenesis
palate development
regulation of cardiac muscle cell proliferation
positive regulation of cardiac muscle cell proliferation
positive regulation of SMAD protein import into nucleus
heart formation
pharyngeal arch artery morphogenesis
cellular response to BMP stimulus
positive regulation of cardiac ventricle development
positive regulation of vascular smooth muscle cell proliferation
regulation of cellular senescence
