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Invitrogen
BRG1 Monoclonal Antibody (GT2712)
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
图: 1 / 15
BRG1 Antibody (MA5-31550) in ICC/IF
BRG1 Monoclonal Antibody (GT2712) detects BRG1 protein at nucleus by immunofluorescent analysis. Sample: HeLa cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: BRG1 protein stained by BRG1 Monoclonal Antibody (GT2712) (Product # MA5-31550) diluted at 1:100. Red: phalloidin, a cytoskeleton marker, diluted at 1:50. Blue: Hoechst 33342 staining.
产品信息
MA5-31550
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
GT2712
抗原
Recombinant protein encompassing a sequence within the N-terminus region of human BRG1.
偶联物
形式
Liquid
浓度
2.44 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787178
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (100%), Rat (100%), Chicken (84%), Bovine (87%).
Positive Control: 293T, K562, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
Brg1 (Brahma-related gene 1) is an ATPase subunit of SWI2/SNF2-like chromatin-remodeling complexes that enable access of regulatory and effector proteins in transcription, DNA repair and DNA replication. Although Brg1-containing complexes are not essential for general cell survival, they participate in transcriptional regulation of several hundred genes including those involved in interferon and stress response, immune cells differentiation, neurogenesis, cell cycle etc. and is absolutely necessary for mouse embryogenesis. Brg1 is also involved in cell growth arrest, senescence and tumour supression.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ATP-dependent helicase SMARCA4; BAF190A; brahma protein-like 1; BRG1-associated factor 190A; BRM/SWI2-related gene 1; FLJ39786; global transcription activator homologous sequence; homeotic gene regulator; Mitotic growth and transcription activator; nuclear protein GRB1; Protein brahma homolog 1; Protein BRG-1; SNF2-beta; SNF2-like 4; sucrose nonfermenting-like 4; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4; Transcription activator BRG1
基因别名: b2b508.1Clo; b2b692Clo; BAF190; BAF190A; brg-1; BRG1; CSS4; HP1-BP72; hSNF2b; MRD16; RTPS2; SMARCA4; SNF2; SNF2B; SNF2beta; SNF2L4; SNF2LB; SW1/SNF; SWI2
UniProt ID: (Human) P51532, (Mouse) Q3TKT4
Entrez Gene ID: (Human) 6597, (Mouse) 20586, (Rat) 171379
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
RNA polymerase II transcription coactivator activity
RNA polymerase I CORE element sequence-specific DNA binding
p53 binding
transcription coactivator activity
transcription corepressor activity
helicase activity
protein binding
ATP binding
DNA-dependent ATPase activity
transcription factor binding
Tat protein binding
nucleosomal DNA binding
protein N-terminus binding
androgen receptor binding
DNA polymerase binding
lysine-acetylated histone binding
nucleotide binding
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
chromatin binding
hydrolase activity
hydrolase activity, acting on acid anhydrides
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
ATPase activity
protein complex binding
histone binding
DNA helicase
negative regulation of transcription from RNA polymerase II promoter
neural retina development
nucleosome disassembly
chromatin remodeling
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
negative regulation of transcription from RNA polymerase II promoter during mitosis
spermatid development
nervous system development
covalent chromatin modification
positive regulation of Wnt signaling pathway
negative regulation of cell growth
ATP-dependent chromatin remodeling
positive regulation by host of viral transcription
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of androgen receptor signaling pathway
positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
positive regulation of glucose mediated signaling pathway
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
beta-catenin-TCF complex assembly
negative regulation of G1/S transition of mitotic cell cycle
cell morphogenesis
blood vessel development
vasculogenesis
in utero embryonic development
blastocyst growth
blastocyst hatching
liver development
outflow tract morphogenesis
nucleosome assembly
methylation-dependent chromatin silencing
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
glial cell fate determination
heart development
positive regulation of cell proliferation
DNA methylation on cytosine within a CG sequence
chromatin modification
stem cell population maintenance
neurogenesis
extracellular matrix organization
keratinocyte differentiation
regulation of cell migration
forebrain development
hindbrain development
embryonic hindlimb morphogenesis
aortic smooth muscle cell differentiation
negative regulation of apoptotic process
positive regulation of DNA binding
histone H3 acetylation
positive regulation of cell differentiation
embryonic organ morphogenesis
epidermis morphogenesis
definitive erythrocyte differentiation
heart trabecula formation
pharyngeal arch artery morphogenesis
lens fiber cell development
