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产品信息
18990-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide
偶联物
形式
Liquid
浓度
260 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Aliquoting is unnecessary for -20°C storage.
靶标信息
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominatly, if not exclusively, in the liver, where it is further localized to the canilicular microvilli and to subcanilicular vesicles fo the hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologus halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. Defects in ABCB11 are the cause of progressive familial intrahepatic cholestasis 2 (PFIC2). PFIC2 is an inherited liver disease of childhood which is characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Defects in ABCB11 are also found in cases of chronic intrahepatic cholestasis without obvious familial history of chronic liver disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ABC member 16, MDR/TAP subfamily; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; ATP-binding cassette, sub-family B, member 11; Bile salt export pump; progressive familial intrahepatic cholestasis 2; Sister of P-glycoprotein; sister p-glycoprotein
基因别名: ABC16; ABCB11; BRIC2; BSEP; Lith1; PFIC-2; PFIC2; PGY4; SPGP
UniProt ID: (Human) O95342, (Mouse) Q9QY30
Entrez Gene ID: (Human) 8647, (Mouse) 27413
transporter activity
ATP binding
sodium-exporting ATPase activity, phosphorylative mechanism
canalicular bile acid transmembrane transporter activity
bile acid-exporting ATPase activity
nucleotide binding
drug transmembrane transporter activity
ATPase activity
ATPase activity, coupled to transmembrane movement of substances
ATP-binding cassette (ABC) transporter
