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Invitrogen
Beclin 1 Monoclonal Antibody (8A8)
高级验证
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
产品信息
MA5-32938
产品规格
种属反应
Human,
Mouse
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
8A8
抗原
Recombinant full length Human Beclin 1.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2802573
产品详细信息
Purity is > 95% by SDS-PAGE.
靶标信息
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; Coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; Protein GT197; testis secretory sperm-binding protein Li 215e
基因别名: 4921513J16Rik; 5430417M23Rik; ATG6; beclin1; BECN1; GT197; VPS30
UniProt ID: (Human) Q14457, (Mouse) O88597
Entrez Gene ID: (Human) 8678, (Mouse) 56208
autophagosome assembly
cytokinesis
response to hypoxia
autophagy
apoptotic process
cellular defense response
cellular response to nitrogen starvation
lysosome organization
mitotic metaphase plate congression
negative regulation of cell proliferation
positive regulation of autophagy
positive regulation of phosphatidylinositol 3-kinase signaling
macroautophagy
positive regulation of macroautophagy
CVT pathway
regulation of cytokinesis
receptor catabolic process
response to vitamin E
cellular response to glucose starvation
response to drug
negative regulation of apoptotic process
engulfment of apoptotic cell
nucleophagy
late endosome to vacuole transport
neuron development
beta-amyloid metabolic process
regulation of catalytic activity
defense response to virus
negative regulation of cell death
cellular response to aluminum ion
cellular response to epidermal growth factor stimulus
mitophagy in response to mitochondrial depolarization
positive regulation of attachment of mitotic spindle microtubules to kinetochore
positive regulation of mitophagy
negative regulation of reactive oxygen species metabolic process
angiogenesis
cell cycle
cell division
response to other organism
