Proteintech

Biglycan Polyclonal Antibody

Biglycan Antibody in Immunocytochemistry (ICC/IF)

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Biglycan Antibody (16409-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells using 16409-1-AP (Biglycan antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

Biglycan Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Biglycan Antibody in Immunoprecipitation (IP)

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产品信息

16409-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

查看12篇已发表文章 12篇已发表文章

免疫组化 (IHC)

查看7篇已发表文章 7篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:20-1:200

查看5篇已发表文章 5篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg

其他PubMed (Misc)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse, Pig, Rat

已发表种属

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Biglycan Fusion Protein Ag0683 (1-368 aa encoded by BC004244)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.22 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MWPLWRLVS LLALSQALPF EQRGFWDFTL DDGPFMMNDE EASGADTSGV LDPDSVTPTY SAMCPFGCHC HLRVVQCSDL GLKSVPKEIS PDTTLLDLQN NDISELRKDD FKGLQHLYAL VLVNNKISKI HEKAFSPLRK LQKLYISKNH LVEIPPNLPS SLVELRIHDN RIRKVPKGVF SGLRNMNCIE MGGNPLENSG FEPGAFDGLK LNYLRISEAK LTGIPKDLPE TLNELHLDHN KIQAIELEDL LRYSKLYRLG LGHNQIRMIE NGSLSFLPTL RELHLDNNKL ARVPSGLPDL KLLQVVYLHS NNITKVGVND FCPMGFGVKR AYYNGISLFN NPVPYWEVQP ATFRCVTDRL AIQFGNYKK (1-368 aa encoded by BC004244 )

靶标信息

BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transferring growth factor-beta. It may promote neuronal survival.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Dissecting the role of cancer-associated fibroblast-derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single-cell transcriptomic study.

Clinical and translational medicine

Zheng S,Liang JY,Tang Y,Xie J,Zou Y,Yang A,Shao N,Kuang X,Ji F,Liu X,Tian W,Xiao W,Lin Y

Wed Feb 01 00:00:00 UTC 2023

Dissecting the role of cancer-associated fibroblast-derived biglycan as a potential therapeutic target in immunotherapy resistance: A tumor bulk and single-cell transcriptomic study.

Clinical and translational medicine

Zheng S,Liang JY,Tang Y,Xie J,Zou Y,Yang A,Shao N,Kuang X,Ji F,Liu X,Tian W,Xiao W,Lin Y

Wed Feb 01 00:00:00 UTC 2023

Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.

Journal of proteome research

Lin Y,Chen M,Wang D,Yu Y,Chen R,Zhang M,Yu H,Huang X,Rao M,Wang Y,Li Y,Yan J,Yin P

Fri Jun 02 00:00:00 UTC 2023

Stroma biglycan expression can be a prognostic factor in prostate cancers.

International journal of urology : official journal of the Japanese Urological Association

Furumido J,Maishi N,Yanagawa-Matsuda A,Kikuchi H,Matsumoto R,Osawa T,Abe T,Matsuno Y,Shinohara N,Hida Y,Hida K

Wed Feb 01 00:00:00 UTC 2023

Establishment of a risk model by integrating hypoxia genes in predicting prognosis of esophageal squamous cell carcinoma.

Cancer medicine

Xiao W,Tang P,Sui Z,Han Y,Zhao G,Wu X,Yang Y,Zhu N,Gong L,Yu Z,Zhang H

Sun Jan 01 00:00:00 UTC 2023

Identification of hub genes and pathways in lung metastatic colorectal cancer.

BMC cancer

Dai W,Guo C,Wang Y,Li Y,Xie R,Wu J,Yao B,Xie D,He L,Li Y,Huang H,Wang Y,Liu S

Thu Apr 06 00:00:00 UTC 2023

Rejuvenation of tendon stem/progenitor cells for functional tendon regeneration through platelet-derived exosomes loaded with recombinant Yap1.

Acta biomaterialia

Lu J,Yang X,He C,Chen Y,Li C,Li S,Chen Y,Wu Y,Xiang Z,Kang J,Jiang G,Wang C,Diarra MD,He R,Feng G,Yan R

Sat Apr 15 00:00:00 UTC 2023

Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy.

Oncoimmunology

Vaxevanis CK,Bauer M,Subbarayan K,Friedrich M,Massa C,Biehl K,Al-Ali HK,Wickenhauser C,Seliger B

Tue Dec 20 00:00:00 UTC 2022

Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.

Oncoimmunology

Subbarayan K,Massa C,Leisz S,Steven A,Bethmann D,Biehl K,Wickenhauser C,Seliger B

Tue May 10 00:00:00 UTC 2022

Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.

Oncoimmunology

Subbarayan K,Massa C,Leisz S,Steven A,Bethmann D,Biehl K,Wickenhauser C,Seliger B

Tue May 10 00:00:00 UTC 2022

Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.

Oncoimmunology

Subbarayan K,Massa C,Leisz S,Steven A,Bethmann D,Biehl K,Wickenhauser C,Seliger B

Tue May 10 00:00:00 UTC 2022

Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells.

Oncoimmunology

Subbarayan K,Massa C,Leisz S,Steven A,Bethmann D,Biehl K,Wickenhauser C,Seliger B

Tue May 10 00:00:00 UTC 2022

Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer Cells.

Cancers

Manupati K,Paul R,Hao M,Haas M,Bian ZC,Holm TM,Guan JL,Yeo SK

Mon Jan 17 00:00:00 UTC 2022

Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer Cells.

Cancers

Manupati K,Paul R,Hao M,Haas M,Bian ZC,Holm TM,Guan JL,Yeo SK

Mon Jan 17 00:00:00 UTC 2022

Identification of key genes and pathways revealing the central regulatory mechanism of brain-derived glucagon-like peptide-1 on obesity using bioinformatics analysis.

Frontiers in neuroscience

Shao Y,Tian J,Yang Y,Hu Y,Zhu Y,Shu Q

Tue Aug 23 00:00:00 UTC 2022

Identification of key genes and pathways revealing the central regulatory mechanism of brain-derived glucagon-like peptide-1 on obesity using bioinformatics analysis.

Frontiers in neuroscience

Shao Y,Tian J,Yang Y,Hu Y,Zhu Y,Shu Q

Tue Aug 23 00:00:00 UTC 2022

Expression and localization of CD63 in the intracellular vesicles of odontoblasts.

Histochemistry and cell biology

Matsuki-Fukushima M,Fujikawa K,Inoue S,Nakamura M

Wed Jun 01 00:00:00 UTC 2022

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer.

Oncoimmunology

Zheng S,Zou Y,Tang Y,Yang A,Liang JY,Wu L,Tian W,Xiao W,Xie X,Yang L,Xie J,Wei W,Xie X

Mon Jan 31 00:00:00 UTC 2022

Landscape of cancer-associated fibroblasts identifies the secreted biglycan as a protumor and immunosuppressive factor in triple-negative breast cancer.

Oncoimmunology

Zheng S,Zou Y,Tang Y,Yang A,Liang JY,Wu L,Tian W,Xiao W,Xie X,Yang L,Xie J,Wei W,Xie X

Mon Jan 31 00:00:00 UTC 2022

Effects of aging on the histology and biochemistry of rat tendon healing.

BMC musculoskeletal disorders

Lai F,Tang H,Wang J,Lu K,Bian X,Wang Y,Shi Y,Guo Y,He G,Zhou M,Zhang X,Zhou B,Zhang J,Chen W,Tang K

Mon Nov 15 00:00:00 UTC 2021

Biglycan, tumor endothelial cell secreting proteoglycan, as possible biomarker for lung cancer.

Thoracic cancer

Morimoto H,Hida Y,Maishi N,Nishihara H,Hatanaka Y,Li C,Matsuno Y,Nakamura T,Hirano S,Hida K

Sat May 01 00:00:00 UTC 2021

Quantitative Proteome of Infant Stenotic Ureters Reveals Extracellular Matrix Organization and Oxidative Stress Dysregulation Underlying Ureteropelvic Junction Obstruction.

Proteomics. Clinical applications

Li Y,Chen Z,Zhang J,Zhang Q,He L,Xu M,Xu G,Geng H,Fang X

Sun Nov 01 00:00:00 UTC 2020

Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway.

Cell death & disease

Cui Q,Xing J,Yu M,Wang Y,Xu J,Gu Y,Nan X,Ma W,Liu H,Zhao H

Wed Feb 20 00:00:00 UTC 2019

Expression and localization of the small proteoglycans decorin and biglycan in articular cartilage of Kashin-Beck disease and rats induced by T-2 toxin and selenium deficiency.

Glycoconjugate journal

Wang M,Xue S,Fang Q,Zhang M,He Y,Zhang Y,Lammi MJ,Cao J,Chen J

Sun Dec 01 00:00:00 UTC 2019

Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.

Cell proliferation

Wang Y,He G,Tang H,Shi Y,Kang X,Lyu J,Zhu M,Zhou M,Yang M,Mu M,Chen W,Zhou B,Zhang J,Tang K

Mon Jul 01 00:00:00 UTC 2019

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells.

Oncoimmunology

Subbarayan K,Leisz S,Wickenhauser C,Bethmann D,Massa C,Steven A,Seliger B

Tue Jan 12 00:00:00 UTC 2021

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells.

Oncoimmunology

Subbarayan K,Leisz S,Wickenhauser C,Bethmann D,Massa C,Steven A,Seliger B

Tue Jan 12 00:00:00 UTC 2021

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells.

Oncoimmunology

Subbarayan K,Leisz S,Wickenhauser C,Bethmann D,Massa C,Steven A,Seliger B

Tue Jan 12 00:00:00 UTC 2021

Biglycan-mediated upregulation of MHC class I expression in HER-2/neu-transformed cells.

Oncoimmunology

Subbarayan K,Leisz S,Wickenhauser C,Bethmann D,Massa C,Steven A,Seliger B

Tue Jan 12 00:00:00 UTC 2021

生物信息学

蛋白别名: Biglycan; bone/cartilage proteclycan 1; Bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; PG S1; PG-S1; small leucine-rich protein 1A; Small proteoglycan I (biglycan), bone (BSPG1) (bone/cartilage proteclycan 1 precursor)

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基因别名: BG; BGN; BSPG1; DSPG1; PG-S1; PGI; SLRR1A

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UniProt ID: (Human) P21810, (Mouse) P28653, (Rat) P47853

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Entrez Gene ID: (Human) 633, (Pig) 397396, (Mouse) 12111, (Rat) 25181

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功能

protein kinase inhibitor activity extracellular matrix structural constituent glycosaminoglycan binding extracellular matrix binding extracellular matrix structural constituent conferring compression resistance

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