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Biglycan Antibody (PA5-18606) in ICC/IF
Immunocytochemistry analysis of Biglycan using Biglycan Polyclonal Antibody (Product # PA5-18606) in paraformaldehyde fixed HepG2 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing Golgi/ER staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).
产品信息
PA5-18606
产品规格
种属反应
Human,
Mouse
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (DRLAIQFGNYKK) corresponding to the C-terminus amino acids of BGN
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_10987214
产品详细信息
This antibody is predicted to react with canine and mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 2,000.
靶标信息
BGN is a small cellular or pericellular matrix proteoglycan that is closely related in structure to two other small proteoglycans, decorin and fibromodulin. The protein and decorin are thought to be the result of a gene duplication. Decorin contains one attached glycosaminoglycan chain, while this protein probably contains two chains. For this reason, this protein is called biglycan. This protein is thought to function in connective tissue metabolism by binding to collagen fibrils and transferring growth factor-beta. It may promote neuronal survival.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Biglycan; Bone/cartilage proteoglycan I; bone/cartilage proteoglycan-I; dermatan sulphate proteoglycan I; PG S1; PG-S1; small leucine-rich protein 1A
基因别名: BG; BGN; DSPG1; PG-S1; PGI; SLRR1A
UniProt ID: (Human) P21810, (Mouse) P28653
Entrez Gene ID: (Human) 633, (Mouse) 12111
peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
blood vessel remodeling
negative regulation of protein kinase activity
biological_process
cytokine-mediated signaling pathway
extracellular matrix organization
glycosaminoglycan metabolic process
chondroitin sulfate biosynthetic process
chondroitin sulfate catabolic process
dermatan sulfate biosynthetic process
negative regulation of JAK-STAT cascade
