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产品信息
PA5-20002
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to 14 amino acids near the carboxy terminus of human Bmf.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11155393
产品详细信息
In Western blot applications, this antibody detects a band at ~25kDa. A suggested positive control is human kidney tissue lysate.
PA5-20002 can be used with blocking peptide PEP-0124.
靶标信息
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
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生物信息学
蛋白别名: Bcl-2-modifying factor; FLJ00065
基因别名: BMF
UniProt ID: (Human) Q96LC9
Entrez Gene ID: (Human) 90427
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of protein homooligomerization
positive regulation of apoptotic process
anoikis
positive regulation of release of cytochrome c from mitochondria
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
positive regulation of intrinsic apoptotic signaling pathway
