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Bombesin Receptor 2 (GRPR) (extracellular) Polyclonal Antibody

Bombesin Receptor 2 (GRPR) (extracellular) Antibody in Immunocytochemistry (ICC/IF)

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Bombesin Receptor 2 (GRPR) (extracellular) Antibody (ABR-002-200UL) in ICC/IF

Expression of Bombesin receptor 2in human HT-29 cells - Cell surface detection of BB2 receptor in live intact human HT-29 (colorectal adenocarcinoma) cells. Cells were stained with Anti-Bombesin Receptor2 (GRPR) (extracellular) Antibody (#ABR-002) (1:100), followed by goat- Anti-rabbit-AlexaFluor-555 secondary Antibody , showing surface expression of the BB2receptor.

Bombesin Receptor 2 (GRPR) (extracellular) Antibody in Immunohistochemistry (Paraffin) (IHC (P))

Bombesin Receptor 2 (GRPR) (extracellular) Antibody in Western Blot (WB)

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产品信息

ABR-002-200UL

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500

免疫组化（石蜡） (IHC (P))

1:50

免疫细胞化学 (ICC/IF)

1:100

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

(C)RSYHYSEVDTSMLH, corresponding to amino acid residues 287-300 of human BB2R, 3rd extracellular loop

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Lyophilized

浓度

0.8 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.4, with 1% BSA

内含物

0.05% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Reconstitution: 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).

靶标信息

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。