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The epitope recognised by the antibody M81 is domain IV and/or V of the gamma-domain of activated C1s. Monoclonal antibody M81 blocks C4 activation and C4 binding to activated C1s. The antibody reacts around the binding site of C1s and reacts with both active and inactive C1s.
This gene encodes a serine protease, which is a major constituent of the human complement subcomponent C1. C1s associates with two other complement components C1r and C1q in order to yield the first component of the serum complement system. Defects in this gene are the cause of selective C1s deficiency.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: basic proline-rich peptide IB-1; C1 esterase; Complement C1s subcomponent; Complement component 1 subcomponent s
基因别名: C1S
UniProt ID: (Human) P09871
Entrez Gene ID: (Human) 716