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C1orf57 Antibody (PA5-99232) in ICC/IF
Immunofluorescent analysis of C1orf57 in HeLa cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and C1orf57 polyclonal antibody (Product # PA5-99232) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat anti-mouse IgG Alexa Fluor 488 (green).
产品信息
PA5-99232
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NTPCR(Accession Q9BSD7), corresponding to amino acid residues P145-K190.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2818165
产品详细信息
Antibody detects endogenous levels of total C1orf57.
靶标信息
Belonging to the THEP1 NTPase family, C1orf57 (also known as nucleoside triphosphate phosphohydrolase), and its mouse homolog, 2310079N02Rik, are 190 amino acid proteins that has nucleotide phosphatase activity towards ATP, GTP, TTP, CTP and UTP. Acting as a monomer, it also hydrolyzes nucleoside diphosphates with lower efficiency. The gene encoding C1orf57 maps to human chromosome 1, the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinson's, Gaucher disease and Usher syndrome are also associated with chromosome 1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Cancer-related nucleoside-triphosphatase; Cancer-related nucleoside-triphosphatase homolog; NTPase; Nucleoside triphosphate phosphohydrolase; nucleoside-triphosphatase C1orf57 homolog; RP4-659I19.2; RP4-678E16.2
基因别名: 2310079N02Rik; AI449709; C1orf57; HCR-NTPase; NTPCR
UniProt ID: (Human) Q9BSD7, (Mouse) Q9CQA9
Entrez Gene ID: (Human) 84284, (Mouse) 66566
