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产品信息
PA5-76196
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein of human C8orf4.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2719923
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
This gene encodes a small, monomeric, predominantly unstructured protein that functions as a positive regulator of the Wnt/beta-catenin signaling pathway. This protein interacts with a repressor of beta-catenin mediated transcription at nuclear speckles. It is thought to competitively block interactions of the repressor with beta-catenin, resulting in up-regulation of beta-catenin target genes. The encoded protein may also play a role in the NF-kappaB and ERK1/2 signaling pathways. Expression of this gene may play a role in the proliferation of several types of cancer including thyroid cancer, breast cancer and hematological malignancies.
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生物信息学
蛋白别名: human thyroid cancer 1; TC-1; Thyroid cancer protein 1; thyroid cancer-1; Transcriptional and immune response regulator; uncharacterized protein C8orf4 homolog
基因别名: 1110065B09Rik; AW121743; AW321058; C8orf4; TC-1; TC1; TCIM
UniProt ID: (Mouse) Q9D915, (Human) Q9NR00
Entrez Gene ID: (Mouse) 69068, (Human) 56892
apoptotic process
regulation of hemopoiesis
endothelial cell activation involved in immune response
cellular response to heat
positive regulation of NF-kappaB import into nucleus
regulation of DNA-templated transcription in response to stress
negative regulation of Notch signaling pathway
regulation of cell cycle G1/S phase transition
