Proteintech

C9orf72 Polyclonal Antibody

C9orf72 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 8

C9orf72 Antibody (25757-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using 25757-1-AP ( C9orf72 antibody) at dilution of 1:1000 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

C9orf72 Antibody in Immunohistochemistry (PFA fixed) (IHC (PFA))

Product Image Gallery

产品信息

25757-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:300-1:1500

查看4篇已发表文章 4篇已发表文章

免疫组化 (IHC)

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:500-1:2,000

免疫组织化学（多聚甲醛固定） (IHC (PFA))

1:50-1:500

免疫细胞化学 (ICC/IF)

1:50-1:500

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Mouse

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

C9orf72 Fusion Protein Ag22723 (1-221 aa encoded by BC068445)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.33 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

This antibody detects the N-terminal of C9orf72.

Immunogen sequence: MSTLCPPPS PAVAKTEIAL SGKSPLLAAT FAYWDNILGP RVRHIWAPKT EQVLLSDGEI TFLANHTLNG EILRNAESGA IDVKFFVLSE KGVIIVSLIF DGNWNGDRST YGLSIILPQT ELSFYLPLHR VCVDRLTHII RKGRIWMHKE RQENVQKIIL EGTERMEDQG QSIIPMLTGE VIPVMELLSS MKSHSVPEEI DIADTVLNDD DIGDSCHEGF LL (1-221 aa encoded by BC068445)

靶标信息

C9orf72 may play a role in endosomal trafficking and autophagy. It is known to interact with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPSases. C9orf72 localizes in the nucleus, cytoplasm, endosome, lysosome, and autophagosome. Mutations in this gene can result in frontotemporal dementia and/or amyotrophic lateral sclerosis.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

An interaction between synapsin and C9orf72 regulates excitatory synapses and is impaired in ALS/FTD.

Acta neuropathologica

Bauer CS,Cohen RN,Sironi F,Livesey MR,Gillingwater TH,Highley JR,Fillingham DJ,Coldicott I,Smith EF,Gibson YB,Webster CP,Grierson AJ,Bendotti C,De Vos KJ

Thu Sep 01 00:00:00 EDT 2022

Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.

Frontiers in cellular neuroscience

Bauer CS,Webster CP,Shaw AC,Kok JR,Castelli LM,Lin YH,Smith EF,Illanes-Álvarez F,Higginbottom A,Shaw PJ,Azzouz M,Ferraiuolo L,Hautbergue GM,Grierson AJ,De Vos KJ

Wed Aug 16 00:00:00 EDT 2023

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.

Theranostics

Zheng W,Wang K,Wu Y,Yan G,Zhang C,Li Z,Wang L,Chen S

Thu Dec 08 00:00:00 EST 2022

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.

eLife

Laflamme C,McKeever PM,Kumar R,Schwartz J,Kolahdouzan M,Chen CX,You Z,Benaliouad F,Gileadi O,McBride HM,Durcan TM,Edwards AM,Healy LM,Robertson J,McPherson PS

Tue Oct 15 00:00:00 EDT 2019

Implementation of an antibody characterization procedure and application to the major ALS/FTD disease gene C9ORF72.

eLife

Laflamme C,McKeever PM,Kumar R,Schwartz J,Kolahdouzan M,Chen CX,You Z,Benaliouad F,Gileadi O,McBride HM,Durcan TM,Edwards AM,Healy LM,Robertson J,McPherson PS

Tue Oct 15 00:00:00 EDT 2019

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

Nature medicine

Shi Y,Lin S,Staats KA,Li Y,Chang WH,Hung ST,Hendricks E,Linares GR,Wang Y,Son EY,Wen X,Kisler K,Wilkinson B,Menendez L,Sugawara T,Woolwine P,Huang M,Cowan MJ,Ge B,Koutsodendris N,Sandor KP,Komberg J,Vangoor VR,Senthilkumar K,Hennes V,Seah C,Nelson AR,Cheng TY,Lee SJ,August PR,Chen JA,Wisniewski N,Hanson-Smith V,Belgard TG,Zhang A,Coba M,Grunseich C,Ward ME,van den Berg LH,Pasterkamp RJ,Trotti D,Zlokovic BV,Ichida JK