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Immunogen sequence: VAEPELMGT PDGTCYPPPP VPRQASPQNL GTPGLLHPQT SPLLHSLVGQ HILSVQQFTK DQMSHLFNVA HTLRMMVQKE RSLDILKGKV MASMFYEVST RTSSSFAAAM ARLGGAVLSF SEATSSVQKG ESLADSVQTM SCYADVVVLR HPQPGAVELA AKHCRRPVIN AGDGVGEHPT QALLDIFTIR EELGTVNGMT ITMVGDLKHG RTVHSLACLL TQYRVSLRYV APPSLRMPPT VRAFVASRGT KQEEFESIEE ALPDTDVLYM TRIQKERFGS TQEYEACFGQ FILTPHIMTR AKKKMVVMHP MPRVNEISVE VDSDPRAAYF RQAENGMYIR MALLATVLGR F (502-851 aa encoded by BC014178)
The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: CAD trifunctional protein; Carbamoyl phosphate synthetase 2-aspartate transcarbamylase-dihydroorotase; Multifunctional protein CAD
基因别名: CAD; CDG1Z
UniProt ID: (Human) P27708
Entrez Gene ID: (Human) 790