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This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: call5; calmodulin-like 5; Calmodulin-like protein 5; Calmodulin-like skin protein
基因别名: CALML5; CLSP
UniProt ID: (Human) Q9NZT1
Entrez Gene ID: (Human) 51806