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Recommended positive controls: 293T, H1299, Molt-4, Raji, mouse heart.
Predicted reactivity: Mouse (94%), Rat (93%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. As with CARMA1, the CARD domain of CARMA3 has been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-Kappa-B activation. When expressed in cells, this protein binds to BCL10 and activates NF-Kappa-B Recent experiments have shown that CARMA3 is required for EGF-induced NF-Kappa-B activation and contributes to tumor growth in vivo, suggesting that CARMA3 may serve as a new therapeutic target for the treatment of EGFR-driven tumors.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bcl10 binding protein and activator of NFKB; Bcl10-interacting MAGUK protein 1; Bimp1; CARD-containing MAGUK 3 protein; CARD-containing MAGUK protein 3; Carma 3; caspase recruitment domain family, member 10; Caspase recruitment domain-containing protein 10
基因别名: AI449026; BIMP1; CARD10; CARMA3
UniProt ID: (Human) Q9BWT7, (Mouse) P58660
Entrez Gene ID: (Human) 29775, (Mouse) 105844