Proteintech

CARS Polyclonal Antibody

CARS Antibody in Immunocytochemistry (ICC/IF)

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CARS Antibody (15296-1-AP) in ICC/IF

Immunofluorescent analysis of MCF-7 cells, using CARS antibody 15296-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

CARS Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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产品信息

15296-1-AP

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化（石蜡） (IHC (P))

1:20-1:200

免疫细胞化学 (ICC/IF)

1:10-1:100

免疫沉淀 (IP)

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产品规格

种属反应

Human, Mouse

已发表种属

Not Applicable

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

CARS Fusion Protein Ag7546 (1-353 aa encoded by BC002880)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.47 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: MADSSGQQG KGRRVQPQWS PPAGTQPCRL HLYNSLTRNK EVFIPQDGKK VTWYCCGPTV YDASHMGHAR SYISFDILRR VLKDYFKFDV FYCMNITDID DKIIKRARQN HLFEQYREKR PEAAQLLEDV QAALKPFSVK LNETTDPDKK QMLERIQHAV QLATEPLEKA VQSRLTGEEV NSCVEVLLEE AKDLLSDWLD STLGCDVTDN SIFSKLPKFW EGDFHRDMEA LNVLPPDVLT RVSEYVPEIV NFVQKIVDNG YGYVSNGSVY FDTAKFASSE KHSYGKLVPE AVGDQKALQE GEGDLSISAD RLSEKRSPND FALWKASKPG EPSWPCPWGK GRPGWHIECS AMAG (1-353 aa encoded by BC002880)

靶标信息

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Mass spectrometry-based identification of new anti-Ly and known antisynthetase autoantibodies.

Annals of the rheumatic diseases

Vulsteke JB,Derua R,Dubucquoi S,Coutant F,Sanges S,Goncalves D,Wuyts G,De Haes P,Blockmans D,Wuyts WA,Claeys KG,De Langhe E,Fabien N,Bossuyt X

Sat Apr 01 00:00:00 EDT 2023

Mass spectrometry-based identification of new anti-Ly and known antisynthetase autoantibodies.

Annals of the rheumatic diseases

Vulsteke JB,Derua R,Dubucquoi S,Coutant F,Sanges S,Goncalves D,Wuyts G,De Haes P,Blockmans D,Wuyts WA,Claeys KG,De Langhe E,Fabien N,Bossuyt X

Sat Apr 01 00:00:00 EDT 2023

CARS senses cysteine deprivation to activate AMPK for cell survival.

The EMBO journal

Yuan M,Yan R,Zhang Y,Qiu Y,Jiang Z,Liu H,Wang Y,Sun L,Zhang H,Gao P

Tue Nov 02 00:00:00 EDT 2021

生物信息学

蛋白别名: CysRS; cysteine translase; cysteine tRNA ligase 1, cytoplasmic; Cysteine--tRNA ligase, cytoplasmic; Cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase, cytoplasmic

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基因别名: CA3; CARS; CARS1; CYSRS; MGC:11246

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UniProt ID: (Human) P49589, (Mouse) Q9ER72

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Entrez Gene ID: (Human) 833, (Mouse) 27267

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功能

tRNA binding cysteine-tRNA ligase activity protein binding ATP binding protein homodimerization activity metal ion binding nucleotide binding aminoacyl-tRNA ligase activity ligase activity aminoacyl-tRNA synthetase

参与通路

tRNA aminoacylation for protein translation cysteinyl-tRNA aminoacylation translation