Invitrogen

CARS Polyclonal Antibody

高级验证

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

查看其他18个CARS抗体

说明书

实验方案

技术支持

说明书

实验方案

技术支持

抗体检测数据 (7)
高级验证 (1)

CARS Antibody in Immunohistochemistry (IHC)

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CARS Antibody (PA5-51709) in IHC

Immunohistochemical staining of CARS in human cerebral cortex, pancreas, skeletal muscle and testis using CARS Polyclonal Antibody (Product # PA5-51709) (A) shows similar protein distribution across tissues to an independent CARS Polyclonal Antibody (B).

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CARS Antibody — Relative expression in different tissues in IHC: Detection of differential expression levels of CARS demonstrates antibody specificity. Immunohistochemical analysis of CARS using anti-CARS Polyclonal Antibody (Product # PA5-51709), shows significant staining of CARS in human cerebral cortex and shows minimal or weak staining in human skeletal muscle tissues. The relative expression levels of CARS within each tissue is shown using RNA-Seq. {RE}

产品信息

PA5-51709

应用

建议稀释比

已发表文章

免疫印迹 (WB)

0.04-0.4 µg/mL

免疫组化 (IHC)

1:50-1:200

免疫细胞化学 (ICC/IF)

0.25-2 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein corresponding to Human CARS. Recombinant protein control fragment (Product #RP-101867).

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.1 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.2, with 40% glycerol

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Wet ice

RRID

AB_2639295

产品详细信息

Immunogen sequence: SQCNLYMAAR KAVRKRPNQA LLENIALYLT HMLKIFGAVE EDSSLGFPVG GPGTSLSLEA TVMPYLQVLS EFREGVRKIA REQKVPEILQ LSDALRDNIL PELGVRFEDH EGLPTVVKLV DRNTLLKERE EKRRVE

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

靶标信息

This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: CysRS; cysteine translase; cysteine tRNA ligase 1, cytoplasmic; Cysteine--tRNA ligase, cytoplasmic; Cysteinyl-tRNA synthetase; cysteinyl-tRNA synthetase, cytoplasmic

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基因别名: CA3; CARS; CARS1; CYSRS; MGC:11246

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UniProt ID: (Human) P49589, (Mouse) Q9ER72

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Entrez Gene ID: (Human) 833, (Mouse) 27267, (Rat) 293638

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功能

tRNA binding cysteine-tRNA ligase activity protein binding ATP binding protein homodimerization activity metal ion binding nucleotide binding aminoacyl-tRNA ligase activity ligase activity aminoacyl-tRNA synthetase

参与通路

tRNA aminoacylation for protein translation cysteinyl-tRNA aminoacylation translation