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Polycomb group (PcG) proteins are chromatin-associated proteins which are important for embryonic and adult stem cell self-renewal and maintenance. At least two distinct human PcG complexes have been identified. Polycomb repressive complex I (PRC1) contains CBX4/Pc2, HPH1 and RING domain-containing proteins (RING1, RING2 and BMI1). CBX4 (Chromobox protein homolog 4 or PC2), which functions as a transcriptional suppressor, is a candidate of KyoT2-binding proteins. It is a E3 SUMO-protein ligase which facilitates SUMO1 conjugation. Depletion of CBX4 results in decreased cellular resistance to ionizing radiation. CBX4 is directly involved in the cellular response to DNA damage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: chromobox homolog 4; chromobox homolog 4 (Pc class homolog, Drosophila); Chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; E3 SUMO-protein transferase CBX4; hPc2; NS5ATP1-binding protein 16; Pc class 2 homolog; Pc2; Polycomb 2 homolog
基因别名: CBX4; MPc2; NBP16; PC2
UniProt ID: (Human) O00257, (Mouse) O55187
Entrez Gene ID: (Human) 8535, (Mouse) 12418, (Rat) 501403