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产品信息
BS-1666R
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide derived from human CCL21, amino acids 24-134.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
内含物
0.02% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 6 Ckine; 6Ckine; beta chemokine exodus-2; Beta-chemokine exodus-2; C-C motif chemokine 21; C-C motif chemokine 21a; C-C motif chemokine 21b; C-C motif chemokine 21c; CC chemokine 6Ckine-ser; Ccl21-leu; CCL21-Ser; chemokine (C-C motif) ligand 21; chemokine (C-C motif) ligand 21b (serine); Efficient Chemoattractant for Lymphocytes; exodus-2; secondary lymphoid organ chemokine; secondary lymphoid tissue chemokine; Secondary lymphoid-tissue chemokine; SLC; small inducible cytokine A21; small inducible cytokine A21a; small inducible cytokine A21c; small inducible cytokine subfamily A (Cys-Cys), member 21; Small-inducible cytokine A21; Small-inducible cytokine A21a; Small-inducible cytokine A21b; Small-inducible cytokine A21c; TCA4; Thymus-derived chemotactic agent 4
基因别名: 6CKBAC1; 6CKBAC2; 6Ckine; AI159701; ALP; AW987545; CCL21; Ccl21a; Ccl21b; Ccl21c; CKb9; ECL; exodus-2; plt; SCYA21; SCYA21a; Scya21b; Scya21c; SLC; TCA4; UNQ784/PRO1600
UniProt ID: (Human) O00585, (Mouse) P84444, (Mouse) P86792
Entrez Gene ID: (Human) 6366, (Rat) 298006, (Mouse) 18829, (Mouse) 100042493, (Mouse) 65956
establishment of T cell polarity
immunological synapse formation
positive regulation of cell-matrix adhesion
dendritic cell chemotaxis
monocyte chemotaxis
positive regulation of dendritic cell antigen processing and presentation
inflammatory response
immune response
G-protein coupled receptor signaling pathway
cell-cell signaling
positive regulation of glycoprotein biosynthetic process
positive regulation of actin filament polymerization
positive regulation of pseudopodium assembly
T cell costimulation
ruffle organization
positive regulation of cell adhesion mediated by integrin
response to prostaglandin E
mesangial cell-matrix adhesion
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of protein kinase activity
positive regulation of JNK cascade
lymphocyte chemotaxis
positive regulation of receptor-mediated endocytosis
cell maturation
positive regulation of chemotaxis
release of sequestered calcium ion into cytosol
positive regulation of filopodium assembly
positive regulation of protein kinase B signaling
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
cellular response to interferon-gamma
cellular response to interleukin-1
cellular response to tumor necrosis factor
positive regulation of neutrophil chemotaxis
activation of GTPase activity
dendritic cell dendrite assembly
negative regulation of leukocyte tethering or rolling
negative regulation of leukocyte apoptotic process
positive regulation of cell motility
positive regulation of T cell migration
positive regulation of myeloid dendritic cell chemotaxis
negative regulation of dendritic cell dendrite assembly
lymph node development
induction of positive chemotaxis
leukocyte chemotaxis
negative regulation of myeloid cell differentiation
