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CCR2 Antibody (PA5-23037) in IHC (P)
Immunohistochemical analysis of CCR2 in formalin-fixed paraffin-embedded section of human esophageal squamous cell carcinoma (SCC). Samples were incubated in CCR2 polyclonal antibody (Product # PA5-23037) using a dilution of 5 µg/mL. Strong cytoplasmic-membranous immune-staining was observed in SCC cells and a relatively weaker staining was seen in the tumor stroma cells. [Magnification 10X].
产品信息
PA5-23037
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Cat,
Human,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide made to an N-terminal portion of the human CCR2 protein (within residues 20-100).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_11153363
靶标信息
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; Cc-ckr2; CCR-2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; chemokine receptor CCR2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
基因别名: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
UniProt ID: (Human) P41597, (Rat) O55193
Entrez Gene ID: (Bovine) 539002, (Cat) 100049057, (Human) 729230, (Rat) 60463
chemokine receptor activity
C-C chemokine receptor activity
protein kinase binding
CCR2 chemokine receptor binding
protein homodimerization activity
chemokine (C-C motif) ligand 5 binding
cytokine binding
chemokine binding
C-C chemokine binding
chemokine (C-C motif) ligand 2 binding
chemokine (C-C motif) ligand 12 binding
chemokine (C-C motif) ligand 7 binding
response to hypoxia
blood vessel remodeling
inflammatory response to antigenic stimulus
monocyte chemotaxis
positive regulation of T-helper 1 type immune response
negative regulation of type 2 immune response
cellular calcium ion homeostasis
inflammatory response
immune response
humoral immune response
cellular defense response
G-protein coupled receptor signaling pathway
regulation of vascular endothelial growth factor production
positive regulation of T cell chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
sensory perception of pain
cellular homeostasis
hemopoiesis
regulation of cell migration
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of tumor necrosis factor production
T-helper 17 cell chemotaxis
positive regulation of tumor necrosis factor biosynthetic process
negative regulation of eosinophil degranulation
positive regulation of MAPK cascade
positive regulation of alpha-beta T cell proliferation
positive regulation of inflammatory response
positive regulation of T cell activation
response to hyperoxia
chemokine-mediated signaling pathway
positive regulation of monocyte chemotaxis
positive regulation of immune complex clearance by monocytes and macrophages
positive regulation of monocyte extravasation
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of astrocyte chemotaxis
positive regulation of hematopoietic stem cell migration
dendritic cell chemotaxis
chemotaxis
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
aging
response to wounding
response to ionizing radiation
positive regulation of gene expression
negative regulation of cell migration
negative regulation of axon extension
forebrain development
positive regulation of fever generation
response to lipopolysaccharide
positive regulation of interleukin-6 production
defense response to bacterium
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of interleukin-1 beta secretion
positive regulation of apoptotic process by virus
neuron death
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of neural precursor cell proliferation
