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Invitrogen
CCR2 Recombinant Superclonal Antibody
高级验证
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
图: 1 / 3
CCR2 Antibody (711255) in ICC/IF
For immunofluorescence analysis, THP-1 cells were fixed and permeabilized for detection of endogenous CCR2 using CCR2 Recombinant Rabbit Polyclonal Antibody (Product # 711255, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of CCR2 protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Pane... View More
产品信息
711255
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Superclonal
类型
Antibody
抗原
Peptides corresponding to Human CCR2 (aa 6-19, 356-372)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2633142
产品详细信息
This antibody is predicted to react with Monkey, Sheep, Bovine and Goat.
Recombinant rabbit polyclonal antibodies are unique offerings from Thermo Fisher Scientific. They are comprised of a selection of multiple different recombinant monoclonal antibodies, providing the best of both worlds - the sensitivity of polyclonal antibodies with the specificity of monoclonal antibodies - all delivered with the consistency only found in a recombinant antibody. While functionally the same as a polyclonal antibody - recognizing multiple epitope sites on the target and producing higher detection sensitivity for low abundance targets - a recombinant rabbit polyclonal antibody has a known mixture of light and heavy chains. The exact population can be produced in every lot, circumventing the biological variability typically associated with polyclonal antibody production.
靶标信息
CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: C-C chemokine receptor type 2; C-C CKR-2; Cc-ckr2; CD192; CD192 antigen; chemokine (C-C motif) receptor 2; hCG_14621; MCP-1 receptor; MCP-1-R; Mcp1 receptor; Mcp1r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor
基因别名: CC-CKR-2; CCR-2; CCR2; CCR2A; CCR2B; CD192; CKR2; CKR2A; CKR2B; CMKBR2; MCP-1-R
UniProt ID: (Human) P41597
Entrez Gene ID: (Human) 729230
blood vessel remodeling
dendritic cell chemotaxis
inflammatory response to antigenic stimulus
positive regulation of T-helper 1 type immune response
negative regulation of type 2 immune response
cellular calcium ion homeostasis
chemotaxis
inflammatory response
immune response
cellular defense response
G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
JAK-STAT cascade
aging
response to wounding
response to ionizing radiation
regulation of vascular endothelial growth factor production
positive regulation of gene expression
positive regulation of T cell chemotaxis
negative regulation of angiogenesis
cytokine-mediated signaling pathway
cellular homeostasis
negative regulation of cell migration
negative regulation of axon extension
forebrain development
positive regulation of fever generation
response to lipopolysaccharide
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-6 production
T-helper 17 cell chemotaxis
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
negative regulation of eosinophil degranulation
fat cell differentiation
positive regulation of neuron differentiation
positive regulation of alpha-beta T cell proliferation
positive regulation of interleukin-1 beta secretion
positive regulation of inflammatory response
positive regulation of T cell activation
positive regulation of apoptotic process by virus
chemokine-mediated signaling pathway
neuron death
positive regulation of monocyte chemotaxis
positive regulation of cell migration involved in sprouting angiogenesis
positive regulation of immune complex clearance by monocytes and macrophages
negative regulation of neural precursor cell proliferation
positive regulation of monocyte extravasation
positive regulation of CD8-positive, alpha-beta T cell extravasation
positive regulation of astrocyte chemotaxis
positive regulation of hematopoietic stem cell migration
