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Invitrogen
CCR7 Polyclonal Antibody
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CCR7 Antibody (PA5-85613) in WB
Western blot analysis of CCR7 in whole cell extract using CCR7 polyclonal antibody (Product # PA5-85613) using 30 µg of sample at a dilution of 1:500. Sample was then incubated with Hoechst secondary antibody. Prior to incubation with primary antibody, the sample was separated on 10% SDS-PAGE.
产品信息
PA5-85613
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the C-terminus region of human CCR7.
偶联物
形式
Liquid
浓度
1.06 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Keep as concentrated solution.
Predicted reactivity: Mouse (87%), Rat (88%), Pig (93%), Rhesus Monkey (100%), Bovine (95%).
Positive Control: HeLa, HepG2, MCF-7.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC (secondary lymphoid-tissue chemokine), CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naive from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC's. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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