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CCR7 (extracellular) Antibody (PA5-111767) in WB
Western Blot analysis of CCR7 was performed in Jurkat (lanes 1 and 4), MOLT-4 (lanes 2 and 5) and J774A.1 (lanes 3 and 6) cell lysates. Lane 1-3: CCR7 (extracellular) Antibody (Product # PA5-111767) at a dilution of 1:200. Lane 4-6: CCR7 (extracellular) Antibody preincubated with the negative control antigen.
产品信息
PA5-111767
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide corresponding to amino acid residues 26-40 of human CCR7 (Extracellular, N-terminus)
偶联物
Unconjugated
形式
Lyophilized
浓度
0.8 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2857177
产品详细信息
Reconstitute antibody with 50 µL of double distilled water (DDW). The reconstituted solution can be stored at 4 degrees C for up to 1 week. For longer periods, small aliquots should be stored at -20 degrees C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Peptide sequence is: (C)DEVTDDY IGDNTTVD
Homology: Rat, mouse - 14/15 amino acid residues identical.
靶标信息
CCR7 is a member of the G protein coupled receptor family, which is a subfamily of chemokines. CCR7 was identified to be induced by the Epstein Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. CCR7 has been reported to be expressed in blood, bone marrow, lymph node, and intestine. CCR7 is particularly expressed in lymphoid tissues and in activated B and T lymphocytes and has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. ESTs have been isolated from blood, embryo, lymph node, and thymus libraries. Receptors for the C - C chemokine family include CCR 1, CCR 2A, CCR 3, CCR 4, CCR 5 and the Duffy blood group antigen. The C-C receptors are important in the function of T cell chemotaxis and migration of phagocytic cells to sites of inflammation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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