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CCR8 Antibody (PA5-96908) in WB
Western blot analysis of CCR8 in extracts of various cell lines. Samples were incubated with CCR8 Polyclonal antibody (Product # PA5-96908) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-96908
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 296-355 of human CCR8 (NP_0051921)
偶联物
形式
Liquid
浓度
0.8 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
AB_2808710
产品详细信息
Immunogen sequence: NPVIYAFVGE KFKKHLSEIF QKSCSQIFNY LGRQMPRESC EKSSSCQQHS SRSSSVDYIL; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Multi-pass membrane protein
靶标信息
CCR8 encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. CCR8 expression has been reported in spleen and thymus, natural-killer cells, monocytes, and T cells, and at lower levels in peripheral blood leukocytes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: C-C chemokine receptor type 8; C-C CKR-8; C-C motif chemokine receptor 8; cd198; CDw198; chemokine (C-C motif) receptor 8; MGC129966; MGC129973
基因别名: C-C; C-C CKR-8; CC-CKR-8; CCR-8; Ccr8; CKR-8; Cmkbr8; mCCR8; Ter1
UniProt ID: (Mouse) P56484
Entrez Gene ID: (Rat) 301066, (Mouse) 12776
