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CD140b (PDGFRB) Antibody (MA5-28128) in Flow
Flow cytometry of CD140b (PDGFRB) in human myeloid dendritic cells. Samples were incubated with CD140b (PDGFRB) monoclonal antibody (Product # MA5-28128). Image details are as follows: A) Cultured human mdcs consisted of small, triangular adherent cells and small, round floating cells. B) Proliferation curve of one normal human mdc preparation (pN1) and one DMD mdc preparation (pD1). C) Representative images showing the expression of NG2 (green), D) CD49b (green), E) CD29 (green) and F) CD44 (green) by pN1 human mdcs. Nuclei were counterst... View More
产品信息
MA5-28128
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
PR7212
抗原
Human skin fibroblast cell membrane extracts
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
<0.1% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2745111
产品详细信息
This antibody recognizes the extracellular domain of the human PDGF receptor beta subunit.
靶标信息
PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
基因别名: CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT
UniProt ID: (Human) P09619
Entrez Gene ID: (Human) 5159
protein tyrosine kinase activity
platelet activating factor receptor activity
platelet-derived growth factor-activated receptor activity
platelet-derived growth factor beta-receptor activity
Ras guanyl-nucleotide exchange factor activity
receptor binding
platelet-derived growth factor receptor binding
protein binding
ATP binding
protein kinase binding
vascular endothelial growth factor binding
phosphatidylinositol 3-kinase binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
platelet-derived growth factor binding
transmembrane signal receptor
MAPK cascade
glycosaminoglycan biosynthetic process
signal transduction
G-protein coupled receptor signaling pathway
positive regulation of cell proliferation
response to toxic substance
positive regulation of phospholipase C activity
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
cell migration
peptidyl-tyrosine phosphorylation
positive regulation of cell migration
response to estradiol
positive regulation of phosphoprotein phosphatase activity
response to retinoic acid
regulation of actin cytoskeleton organization
positive regulation of collagen biosynthetic process
response to fluid shear stress
cell migration involved in vasculogenesis
metanephric mesenchymal cell migration
platelet-derived growth factor receptor-beta signaling pathway
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
aorta morphogenesis
cellular response to platelet-derived growth factor stimulus
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway
wound healing
response to hydrogen peroxide
negative regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of mitotic nuclear division
phosphatidylinositol metabolic process
protein autophosphorylation
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of smooth muscle cell proliferation
inner ear development
positive regulation of chemotaxis
cardiac myofibril assembly
response to hyperoxia
cell chemotaxis
cell migration involved in coronary angiogenesis
retina vasculature development in camera-type eye
positive regulation of ERK1 and ERK2 cascade
smooth muscle cell chemotaxis
metanephric mesenchyme development
metanephric glomerular mesangial cell proliferation involved in metanephros development
metanephric glomerular capillary formation
metanephric comma-shaped body morphogenesis
metanephric S-shaped body morphogenesis
positive regulation of calcium ion import
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
