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CD148 Antibody (PA5-119082) in IHC (P)
Immunohistochemistry analysis of CD148 in paraffin-embedded Mouse Stomach tissue. Samples were incubated with polyclonal antibody (Product # PA5-119082) at a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG using a dilution of 2 µg/mL.
产品信息
PA5-119082
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Density Enhanced Phosphatase 1. The antigen corresponds to amino acid range 567-842 of the target protein.
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903582
靶标信息
CD148 is a highly glycosylated transmembrane protein of up to 250 kDa, containing eight fibronectin type III domains in the extracellular region and one tyrosine phosphatase domain in the cytoplasmic region. Expression is found broadly on fibroblasts, epithelial cells, lymphocytes (B, T and NK cells), and myeloid cells (monocytes and granulocytes). CD148 can dephosphorylate proteins such as LAT and PLC-gamma, and is involved in the downregulation of T cell activation. Conversely, CD148 expression can be upregulated following T cell activation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD148; colon tumor susceptibility 1; HPTP beta-like tyrosine phosphatase; Protein-tyrosine phosphatase eta; Protein-tyrosine phosphatase receptor type J; R-PTP-eta; R-PTP-J; Receptor-type tyrosine-protein phosphatase eta; Susceptibility to colon cancer 1
基因别名: AI450271; BET; Byp; CD148; DEP-1; Ptpb2; PTPbeta2; Ptprj; RPTPJ; Scc-1; Scc1
UniProt ID: (Mouse) Q64455
Entrez Gene ID: (Mouse) 19271
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
platelet-derived growth factor receptor binding
beta-catenin binding
hydrolase activity
phosphatase activity
protein kinase binding
gamma-catenin binding
mitogen-activated protein kinase binding
delta-catenin binding
transmembrane signal receptor
vasculogenesis
positive regulation of cell-matrix adhesion
protein dephosphorylation
heart development
blood coagulation
negative regulation of cell proliferation
positive regulation of platelet activation
negative regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of macrophage chemotaxis
dephosphorylation
regulation of cell adhesion
negative regulation of cell growth
negative regulation of cell migration
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of vascular permeability
negative regulation of MAP kinase activity
positive regulation of cell adhesion
platelet-derived growth factor receptor signaling pathway
oligodendrocyte differentiation
negative regulation of T cell receptor signaling pathway
positive chemotaxis
positive regulation of focal adhesion assembly
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
negative regulation of receptor activity
