Invitrogen

CD150 Monoclonal Antibody (SLAM.4), Alexa Fluor™ 647

图: 1 / 2

CD150 Antibody (MA5-44145) in Flow

Separation of human CD150 positive lymphocytes (red-filled) from CD150 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD150 (SLAM.4) Alexa Fluor® 647 Monoclonal antibody (Product # MA5-44145) using a dilution of 4 µL reagent/100 µL of peripheral whole blood.

Product Image Gallery

产品信息

MA5-44145

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent

流式细胞分析 (Flow)

4 µL/1x10^6 cells

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

SLAM.4

抗原

Human CD150-transfected 300.19 cells

查看免疫原

偶联物

Alexa Fluor™ 647 Alexa Fluor™ 647 Alexa Fluor™ 647

激发/发射光谱

650/671 nm 查看光谱

形式

Liquid

纯化类型

Size-exclusion chromatography

保存液

PBS with 0.2% BSA

内含物

15mM sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2913077

产品详细信息

This antibody recognizes an extracellular epitope of CD150, a cell surface molecule expressed on lymphocytes and involved in their activation.

靶标信息

CD150 (SLAM, Signaling Lymphocyte Activation Molecule) belongs to the immunoglobulin gene superfamily, and is involved in T cell stimulation. SLAM is constitutively expressed on peripheral blood memory T cells, T cell clones, immature thymocytes, and a proportion of B cells, and is rapidly induced on naive T cells after activation. Activated B cells express the membrane bound form, the soluble form and the cytoplasmic isoforms of SLAM. It is suggested that signalling through homophilic SLAM-SLAM binding during B to B and B to T cell interactions enhances the expansion and differentiation of activated B cells. Reports suggest that the extracellular domain of CD150 is the receptor for the measles virus and acts as a co-activator on T cells and B cells. Moreover, CD150 is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations CD150 gene may be associated with X-linked lympho-proliferative disease (XLP).

仅用于科研。不用于诊断过程。未经明确授权不得转售。