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CD154 (CD40 Ligand) Antibody (PA5-114715) in ICC/IF
Immunocytochemistry analysis of CD154 (CD40 Ligand) in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-114715). Secondary staining was applied with mouse anti-beta tubulin (1 hr at 37°, AlexaFluor 594 conjugated goat anti-rabbit IgG (Red), AlexaFluor 488 conjugated goat anti-mouse IgG ... View More
产品信息
PA5-114715
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human CD40LG(Accession P29965), corresponding to amino acid residues E92-E142.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2899351
产品详细信息
Antibody detects endogenous levels of total CD40L.
靶标信息
CD40 Ligand (CD40-L), or CD154, is a membrane glycoprotein and differentiation antigen expressed on the surface of T cells. The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL-2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD154; CD40 antigen ligand; CD40 ligand; CD40 ligand CD154; CD40-L; H-CD-40-L; M-CD-40-L; RP23-153G22.3; T-B cell-activating molecule; T-cell antigen Gp39; TNF-related activation protein; TRAP; tumor necrosis factor (ligand) superfamily member 5; tumor necrosis factor (ligand) superfamily, member 5; Tumor necrosis factor ligand superfamily member 5
基因别名: CD154; CD40L; CD40LG; gp39; hCD40L; HIGM1; IGM; IMD3; T-BAM; TNFSF5; TRAP
UniProt ID: (Human) P29965, (Rat) Q9Z2V2
Entrez Gene ID: (Human) 959, (Rat) 84349
inflammatory response
leukocyte cell-cell adhesion
activation of JUN kinase activity
platelet activation
B cell differentiation
T cell costimulation
positive regulation of interleukin-10 production
positive regulation of interleukin-12 production
positive regulation of interleukin-4 production
tumor necrosis factor-mediated signaling pathway
B cell proliferation
positive regulation of T cell proliferation
negative regulation of apoptotic process
isotype switching
immunoglobulin secretion
regulation of immune response
regulation of immunoglobulin secretion
positive regulation of NF-kappaB transcription factor activity
positive regulation of endothelial cell apoptotic process
positive regulation of immune response to tumor cell
immune response
positive regulation of B cell proliferation
positive regulation of interferon-gamma production
positive regulation of MHC class II biosynthetic process
dendritic cell differentiation
