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产品信息
MA5-43907
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
C1
抗原
Pro24-Ser203 (Accession O75015), with N-terminal His Tag
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2912839
靶标信息
CD16 (FCGR3A) is a 50-65 kDa cell surface molecule that exists in two forms - a transmembranous form expressed by NK cells and some T cells, and a phosphatidylinositol linked form expressed by granulocytes. CD16 is a low affinity receptor for IgG (FcR III), and is an important receptor mediating ADCC by NK cells. Human CD16 is expressed in two forms - FCGR3A and FCGR3B. FCGR3A is associated with the FcepsilonRI-gamma subunit and is responsible for antibody-dependent NK cell cytotoxicity. Mast cell FCGR3A is associated, with FcepsilonRI-beta subunit. Besides IgG, FCGR3A can be triggered also by oligomeric IgE. FCGR3B is a GPI-linked monomeric receptor expressed on neutrophils and is involved in their activation and induction of a pro-adhesive phenotype. Diseases associated with CD16 dysfunction include immunodeficiency 20 and systemic lupus erythematosus.
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生物信息学
蛋白别名: CD16-I; CD16b; Fc fragment of IgG, low affinity IIIb, receptor (CD16b); Fc gamma receptor IIIb; Fc-gamma receptor IIIb (CD 16); Fc-gamma RIII-beta; fc-gamma RIIIb; FcR-10; IgG Fc receptor III-1; Low affinity immunoglobulin gamma Fc region receptor III-B
基因别名: CD16; CD16B; FCG3; FCGR3; FCGR3B; FCR-10; FCRIII; FCRIIIb; IGFR3
UniProt ID: (Human) O75015
Entrez Gene ID: (Human) 2215
