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产品信息
23973-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
CD2 Fusion Protein Ag21122 (1-351 aa encoded by BC033583)
偶联物
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MSFPCKFVA SFLLIFNVSS KGAVSKEITN ALETWGALGQ DINLDIPSFQ MSDDIDDIKW EKTSDKKKIA QFRKEKETFK EKDTYKLFKN GTLKIKHLKT DDQDIYKVSI YDTKGKNVLE KIFDLKIQER VSKPKISWTC INTTLTCEVM NGTDPELNLY QDGKHLKLSQ RVITHKWTTS LSAKFKCTAG NKVSKESSVE PVSCPEKGLD IYLIIGICGG GSLLMVFVAL LVFYITKRKK QRSRRNDEEL ETRAHRVATE ERGRKPQQIP ASTPQNPATS QHPPPPPGHR SQAPSHRPPP PGHRVQHQPQ KRPPAPSGTQ VHQQKGPPLP RPRVQPKPPH GAAENSLSPS SN (1-351 aa encoded by BC033583)
靶标信息
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD2; Erythrocyte receptor; FLJ46032; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
基因别名: CD2; LFA-2; SRBC; T11
UniProt ID: (Human) P06729
Entrez Gene ID: (Human) 914
