Loading ...

Invitrogen

CD206 Polyclonal Antibody

4个已发表图片

11 篇参考文献

查看其他44个CD206 (MMR)抗体

说明书

实验方案

技术支持

货号 PA5-46994

飞享价 CNY 4,755.00 6,424.00

活动截止日期 31-Dec-2025

100 µg

查看价格

批量或定制请求

说明书

实验方案

技术支持

抗体检测数据 (3)
已发表图片 (4)

Application

CD206 Antibody in Immunohistochemistry (Frozen) (IHC (F))

图: 1 / 7

CD206 Antibody (PA5-46994) in IHC (F)

Immunohistochemical analysis of CD206 in perfusion fixed frozen sections of mouse lung. Samples were incubated with CD206 polyclonal antibody (Product # PA5-46994) using a dilution of 25 µg/mL overnight at 4 °C followed by NorthernLights™ 493-conjugated Anti-Goat IgG Secondary Antibody (green) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm of macrophages.

CD206 Antibody in Immunocytochemistry (ICC/IF)

CD206 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

CD206 Antibody in Immunohistochemistry (IHC)

Product Image Gallery

产品信息

PA5-46994

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

查看1篇已发表文章 1篇已发表文章

免疫组化 (IHC)

查看7篇已发表文章 7篇已发表文章

免疫组化（石蜡） (IHC (P))

查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

5-15 µg/mL

免疫细胞化学 (ICC/IF)

查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

0.25 µg per million cells

产品规格

种属反应

Mouse

已发表种属

Mouse, Rat

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Mouse myeloma cell line NS0-derived recombinant mouse MMR/CD206 Leu19-Ala1388

查看免疫原

偶联物

Unconjugated

形式

Lyophilized

浓度

0.2 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS with 5% trehalose

内含物

No Preservative

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2607366

产品详细信息

In direct ELISAs and Western blots, approximately 45% cross-reactivity with recombinant human MMR is observed.

Reconstitute at 0.2 mg/mL in sterile PBS.

靶标信息

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response. CD206 is also expressed on microglia and mato cells of the brain but not astrocytes or neurons. CD206 also mediate the recognition and uptake of a variety of macromolecules, including modified lipoproteins, advanced glycation end (AGEs) products and amyloid b-protein (Abeta). While the normal role of CD206 is associated with cell adhesion and host defense mechanisms, it also has been implicated in the development of atherosclerosis and Amyloid beta deposition in Alzheimer's disease (AD). CD206’s gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. CD206 has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. Other diseases associated with CD206 dysfunction include leprosy and Gaucher’s Disease.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

A system for bioelectronic delivery of treatment directed toward wound healing.

Scientific reports

Baniya P,Tebyani M,Asefifeyzabadi N,Nguyen T,Hernandez C,Zhu K,Li H,Selberg J,Hsieh HC,Pansodtee P,Yang HY,Recendez C,Keller G,Hee WS,Aslankoohi E,Isseroff RR,Zhao M,Gomez M,Rolandi M,Teodorescu M

PA5-46994 was used in Immunohistochemistry-immunofluorescence to develop a wearable bioelectronic system using polydimethylsiloxane (PDMS) and 3D printed molds, along with a printed circuit board (PCB) for controlled delivery of therapeutic treatments, allowing for modular assembly and interchangeable components, demonstrating its potential for improving wound healing in mouse models.

Thu Sep 07 00:00:00 UTC 2023

Enhanced liver X receptor signalling reduces brain injury and promotes tissue regeneration following experimental intracerebral haemorrhage: roles of microglia/macrophages.

Stroke and vascular neurology

Zhang R,Dong Y,Liu Y,Moezzi D,Ghorbani S,Mirzaei R,Lozinski BM,Dunn JF,Yong VW,Xue M

PA5-46994 was used in Immunohistochemistry-immunofluorescence to examine the benefits of enhanced Liver X receptor signalling in experimental intracerebral haemorrhage.

Fri Dec 29 00:00:00 UTC 2023

Quercetin-solid lipid nanoparticle-embedded hyaluronic acid functionalized hydrogel for immunomodulation to promote bone reconstruction.

Regenerative biomaterials

Zhou P,Yan B,Wei B,Fu L,Wang Y,Wang W,Zhang L,Mao Y

PA5-46994 was used in Immunohistochemistry to prove that administering quercetin SLNs encapsulated in a hydrogel can aid bone defect reconstruction in rats, providing new insights for large-scale bone defect repair.

Mon Sep 16 00:00:00 UTC 2024

Ezh2 emerges as an epigenetic checkpoint regulator during monocyte differentiation limiting cardiac dysfunction post-MI.

Nature communications

Rondeaux J,Groussard D,Renet S,Tardif V,Dumesnil A,Chu A,Di Maria L,Lemarcis T,Valet M,Henry JP,Badji Z,Vézier C,Béziau-Gasnier D,Neele AE,de Winther MPJ,Guerrot D,Brand M,Richard V,Durand E,Brakenhielm E,Fraineau S

PA5-46994 was used in Immunohistochemistry to reveal that pharmacological epigenetic modulation of cardiac-infiltrating immune cells may hold promise to limit adverse cardiac remodeling after MI.

Tue Jul 25 00:00:00 UTC 2023

Absence of microglia promotes diverse pathologies and early lethality in Alzheimer's disease mice.

Cell reports

Kiani Shabestari S,Morabito S,Danhash EP,McQuade A,Sanchez JR,Miyoshi E,Chadarevian JP,Claes C,Coburn MA,Hasselmann J,Hidalgo J,Tran KN,Martini AC,Chang Rothermich W,Pascual J,Head E,Hume DA,Pridans C,Davtyan H,Swarup V,Blurton-Jones M

PA5-46994 was used in Flow Cytometry, Immunohistochemistry (Frozen), Western Blot to indicate the protective functions of microglia in reducing CAA, blood-brain barrier dysfunction, and brain calcification.

Tue Jun 14 00:00:00 UTC 2022

Electroacupuncture ameliorates postoperative cognitive dysfunction and associated neuroinflammation via NLRP3 signal inhibition in aged mice.

CNS neuroscience & therapeutics

Sun L,Yong Y,Wei P,Wang Y,Li H,Zhou Y,Ruan W,Li X,Song J

PA5-46994 was used in Western Blotting to investigate the effects of electroacupuncture (EA) on postoperative cognitive dysfunction (POCD) in aged mice.

Tue Mar 01 00:00:00 UTC 2022

Nrf2 Ablation Promotes Alzheimer's Disease-Like Pathology in APP/PS1 Transgenic Mice: The Role of Neuroinflammation and Oxidative Stress.

Oxidative medicine and cellular longevity

Ren P,Chen J,Li B,Zhang M,Yang B,Guo X,Chen Z,Cheng H,Wang P,Wang S,Wang N,Zhang G,Wu X,Ma D,Guan D,Zhao R

Published figure using CD206 polyclonal antibody (Product # PA5-46994) in Immunocytochemistry

Wed Jan 06 00:00:00 UTC 2021

Homotrimer cavin1 interacts with caveolin1 to facilitate tumor growth and activate microglia through extracellular vesicles in glioma.

Theranostics

Wang L,Yang C,Wang Q,Liu Q,Wang Y,Zhou J,Li Y,Tan Y,Kang C

PA5-46994 was used in Immunohistochemistry to study the role Cavin1-Caveolin1 interaction plays in regulating production and function of glioma-EVs.

Tue May 18 00:00:00 UTC 2021

Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.

Glia

Farfara D,Feierman E,Richards A,Revenko AS,MacLeod RA,Norris EH,Strickland S

Published figure using CD206 polyclonal antibody (Product # PA5-46994) in Immunocytochemistry

Mon Jul 01 00:00:00 UTC 2019

Knockdown of circulating C1 inhibitor induces neurovascular impairment, glial cell activation, neuroinflammation, and behavioral deficits.

Glia

Farfara D,Feierman E,Richards A,Revenko AS,MacLeod RA,Norris EH,Strickland S

Published figure using CD206 polyclonal antibody (Product # PA5-46994) in Immunocytochemistry

Mon Jul 01 00:00:00 UTC 2019

Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.

Journal of inflammation (London, England)

Du Y,Ren P,Wang Q,Jiang SK,Zhang M,Li JY,Wang LL,Guan DW

PA5-46994 was used in Immunohistochemistry-immunofluorescence to propose that increased Cannabinoid 2 receptor attenuates inflammation during skin wound healing in mice via the inhibition and regulation of M1 macrophage infiltration (not through the activiation of M2 macrophages).

Wed Mar 30 00:00:00 UTC 2022

Cannabinoid 2 receptor attenuates inflammation during skin wound healing by inhibiting M1 macrophages rather than activating M2 macrophages.

Journal of inflammation (London, England)

Du Y,Ren P,Wang Q,Jiang SK,Zhang M,Li JY,Wang LL,Guan DW

Wed Mar 30 00:00:00 UTC 2022

生物信息学

蛋白别名: CD206; Macrophage mannose receptor 1; MMR

基因别名: AW259686; CD206; MR; Mrc1

UniProt ID: (Mouse) Q61830

Entrez Gene ID: (Mouse) 17533

功能

receptor activity transmembrane signaling receptor activity mannose binding carbohydrate binding

参与通路

endocytosis receptor-mediated endocytosis signal transduction cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4

CD206 Polyclonal Antibody

CD206 Antibody (PA5-46994) in IHC (F)

产品信息

PA5-46994

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

流式细胞分析 (Flow)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

CD206 Polyclonal Antibody

CD206 Antibody (PA5-46994) in IHC (F)

产品信息

PA5-46994

免疫印迹 (WB)

免疫组化 (IHC)

免疫组化（石蜡） (IHC (P))

免疫组化（冰冻） (IHC (F))

免疫细胞化学 (ICC/IF)

流式细胞分析 (Flow)

种属反应

已发表种属

宿主/亚型

分类

类型

抗原

偶联物

形式

浓度

纯化类型

保存液

内含物

保存条件

运输条件

RRID .st0{fill-rule:evenodd;clip-rule:evenodd;fill:#A2A2A2;}

产品详细信息

靶标信息

生物信息学

性能保障

随时为您服务

Your items have has been added!

RRID