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产品信息
MA5-44251
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
BLR028F
抗原
Recombinant protein representing the extracellular domain of human Lymphocyte activation gene 3 (LAG3, residues 23-450).
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
purified
保存液
BBS, pH 7.8-8.6
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Wet ice
RRID
AB_2926381
产品详细信息
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE cell sections.
靶标信息
LAG-3 is a 70-kDa surface glycoprotein belonging to the Ig superfamily with homology to CD4. LAG-3 binds to MHC class II with higher affinity than CD4 and is thought to be involved in the negative regulation of T cell activation and homeostatic proliferation. Surface expression of LAG-3 has been reported on activated T cells (including regulatory T cells) and NK cells. CD8+ T cells usually express LAG-3 at significantly higher levels than CD4+ T cells. Coexpression of LAG-3 and CD49b has been proposed to identify human and mouse Type 1 regulatory T cells (Tr1 cells).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD223; LAG-3; Lymphocyte activation gene 3 protein; lymphocyte-activation gene 3; sLAG 3; sLAG3; soluble LAG 3lymphocyte activating 3; soluble LAG3
基因别名: CD223; FDC; LAG3
UniProt ID: (Human) P18627
Entrez Gene ID: (Human) 3902
