Invitrogen

CD3 Monoclonal Antibody (17A2), eFluor™ 506, eBioscience™

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CD3 Antibody (69-0032-82) in Flow

Staining of BALB/c splenocytes with Anti-Human/Mouse CD45R (B220) APC (Product # 17-0452-82) and 0.25 µg of Rat IgG2b K Isotype Control eFluor® 506 (Product # 69-4031-82) (left) or 0.25 µg of Anti-Mouse CD3 eFluor® 506 (right). Total viable cells were used for analysis.

CD3 Antibody in Immunohistochemistry (IHC)

CD3 Antibody in Immunocytochemistry (ICC/IF)

CD3 Antibody in Immunocytochemistry, Immunohistochemistry (Paraffin) (ICC/IF, IHC (P))

CD3 Antibody in Immunocytochemistry, Immunohistochemistry (ICC/IF, IHC)

CD3 Antibody in Immunohistochemistry (Frozen) (IHC (F))

CD3 Antibody in Immunohistochemistry, Flow Cytometry (IHC, Flow)

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产品信息

69-0032-82

应用

建议稀释比

已发表文章

免疫组化 (IHC)

查看13篇已发表文章 13篇已发表文章

免疫组化（石蜡） (IHC (P))

查看1篇已发表文章 1篇已发表文章

免疫组化（冰冻） (IHC (F))

查看2篇已发表文章 2篇已发表文章

免疫细胞化学 (ICC/IF)

查看4篇已发表文章 4篇已发表文章

流式细胞分析 (Flow)

0.5 µg/test

查看55篇已发表文章 55篇已发表文章

T细胞活化 (TCA)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

17A2

偶联物

eFluor™ 506 eFluor™ 506 eFluor™ 506

激发/发射光谱

419/508 nm 查看光谱

形式

Liquid

浓度

0.2 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2637122

产品详细信息

Description: The 17A2 monoclonal antibody reacts with the mouse CD3 complex. CD3 subunits gamma, delta and epsilon are required for proper assembly, trafficking and surface expression of the TCR complex. CD3 is expressed by thymocytes in a developmentally regulated manner and by all mature T cells. Binding of 17A2 to CD3 initiates the intracellular biochemical pathway resulting in cellular activation and proliferation.

Applications Reported: This 17A2 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This 17A2 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

eFluor® 506 can be excited with the violet laser line (405 nm) and emits at 506 nm. We recommend using a 510/20 band pass filter, or equivalent. Please make sure that your instrument is capable of detecting this fluorochrome.

Excitation: 405 nm; Emission: 506 nm; Laser: Violet Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Wed Oct 11 00:00:00 EDT 2017

Rottlerin as a therapeutic approach in psoriasis: Evidence from in vitro and in vivo studies.

PloS one

Min M,Yan BX,Wang P,Landeck L,Chen JQ,Li W,Cai SQ,Zheng M,Man XY

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Tue Jan 16 00:00:00 EST 2018

The breast tumor microenvironment alters the phenotype and function of natural killer cells.

Cellular & molecular immunology

Krneta T,Gillgrass A,Chew M,Ashkar AA

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Thu Sep 01 00:00:00 EDT 2016

Laminin regulates PDGFRβ(+) cell stemness and muscle development.

Nature communications

Yao Y,Norris EH,Mason CE,Strickland S

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Immunofluorescence

Tue May 03 00:00:00 EDT 2016

CD8(+) T-cell Immune Evasion Enables Oncolytic Virus Immunotherapy.

EBioMedicine

Pourchet A,Fuhrmann SR,Pilones KA,Demaria S,Frey AB,Mulvey M,Mohr I

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Tue Mar 01 00:00:00 EST 2016

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation.

Nature communications

Yang M,Chen S,Du J,He J,Wang Y,Li Z,Liu G,Peng W,Zeng X,Li D,Xu P,Guo W,Chang Z,Wang S,Tian Z,Dong Z

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Wed Sep 07 00:00:00 EDT 2016

TNF-Mediated Restriction of Arginase 1 Expression in Myeloid Cells Triggers Type 2 NO Synthase Activity at the Site of Infection.

Cell reports

Schleicher U,Paduch K,Debus A,Obermeyer S,König T,Kling JC,Ribechini E,Dudziak D,Mougiakakos D,Murray PJ,Ostuni R,Körner H,Bogdan C

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Tue May 03 00:00:00 EDT 2016

Diet-dependent, microbiota-independent regulation of IL-10-producing lamina propria macrophages in the small intestine.

Scientific reports

Ochi T,Feng Y,Kitamoto S,Nagao-Kitamoto H,Kuffa P,Atarashi K,Honda K,Teitelbaum DH,Kamada N

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Wed Jun 15 00:00:00 EDT 2016

IKKβ acts as a tumor suppressor in cancer-associated fibroblasts during intestinal tumorigenesis.

The Journal of experimental medicine

Pallangyo CK,Ziegler PK,Greten FR

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Mon Dec 14 00:00:00 EST 2015

Adjuvants may reduce in vivo transfection levels for DNA vaccination in mice leading to reduced antigen-specific CD8+ T cell responses.

Human vaccines & immunotherapeutics

Rose AH,Hoffmann FW,Hara JH,Urschitz J,Moisyadi S,Hoffmann PR,Bertino P

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Mon May 16 00:00:00 EDT 2016

IL-33 Enhances Humoral Immunity Against Chronic HBV Infection Through Activating CD4(+)CXCR5(+) TFH Cells.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Zhao PW,Shi X,Li C,Ayana DA,Niu JQ,Feng JY,Wang J,Jiang YF

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Mon Jun 01 00:00:00 EDT 2015

Regulation of NKT cell-mediated immune responses to tumours and liver inflammation by mitochondrial PGAM5-Drp1 signalling.

Nature communications

Kang YJ,Bang BR,Han KH,Hong L,Shim EJ,Ma J,Lerner RA,Otsuka M

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Fri Sep 18 00:00:00 EDT 2015

Antibiotics in neonatal life increase murine susceptibility to experimental psoriasis.

Nature communications

Zanvit P,Konkel JE,Jiao X,Kasagi S,Zhang D,Wu R,Chia C,Ajami NJ,Smith DP,Petrosino JF,Abbatiello B,Nakatsukasa H,Chen Q,Belkaid Y,Chen ZJ,Chen W

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Tue Sep 29 00:00:00 EDT 2015

A chitin-like component on sclerotic cells of Fonsecaea pedrosoi inhibits Dectin-1-mediated murine Th17 development by masking β-glucans.

PloS one

Dong B,Li D,Li R,Chen SC,Liu W,Liu W,Chen L,Chen Y,Zhang X,Tong Z,Xia Y,Xia P,Wang Y,Duan Y

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2015

Leukocyte population dynamics and detection of IL-9 as a major cytokine at the mouse fetal-maternal interface.

PloS one

Habbeddine M,Verbeke P,Karaz S,Bobé P,Kanellopoulos-Langevin C

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Flow Cytometry

Wed Jun 10 00:00:00 EDT 2015

Neuronal and nonneuronal cholinergic structures in the mouse gastrointestinal tract and spleen.

The Journal of comparative neurology

Gautron L,Rutkowski JM,Burton MD,Wei W,Wan Y,Elmquist JK

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Immunofluorescence

Fri Nov 01 00:00:00 EDT 2013

Increased incidence of endometrioid tumors caused by aberrations in E-cadherin promoter of mismatch repair-deficient mice.

Carcinogenesis

Kovtun IV,Harris KJ,Jatoi A,Jevremovic D

Published figure using CD3 monoclonal antibody (Product # 69-0032-82) in Immunohistochemistry

Fri Jul 01 00:00:00 EDT 2011

生物信息学

蛋白别名: CD247; CD247 antigen; CD3 antigen, zeta polypeptide; CD3 TCR complex; CD3-zeta/eta; CD3d; CD3e; CD3g; FLJ18683; Leu-4; T cell antigen receptor complex epsilon subunit of T3; T-cell receptor T3 delta chain; T-cell receptor T3 eta chain; T-cell receptor T3 gamma chain; T-cell receptor T3 zeta chain; T-cell surface antigen T3/Leu-4 epsilon chain; T-cell surface glycoprotein CD3 delta chain; T-cell surface glycoprotein CD3 epsilon chain; T-cell surface glycoprotein CD3 gamma chain; T-cell surface glycoprotein CD3 zeta chain; T3/TCR complex

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基因别名: 4930549J05Rik; A430104F18Rik; AI504783; AW552088; Cd247; CD3; Cd3-eta; Cd3-zeta; Cd3d; Cd3e; CD3epsilon; Cd3g; Cd3h; Cd3z; Cd3zeta; Ctg-3; Ctg3; T3d; T3e; T3g; T3z; Tcrk; Tcrz

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Entrez Gene ID: (Mouse) 12503, (Mouse) 12500, (Mouse) 12501, (Mouse) 12502

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功能

transmembrane signaling receptor activity protein binding identical protein binding protein heterodimerization activity signal transducer activity SH3 domain binding defense/immunity protein immunoglobulin receptor superfamily

参与通路

CD3 Monoclonal Antibody (17A2), eFluor™ 506, eBioscience™

CD3 Antibody (69-0032-82) in Flow

产品信息

69-0032-82

免疫组化 (IHC)

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流式细胞分析 (Flow)

T细胞活化 (TCA)

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