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产品信息
CD3-4-8-A
应用
建议稀释比
已发表文章
产品规格
已发表种属
Mouse
宿主/亚型
Mouse
/ IgG2a
分类
Cocktail
类型
Antibody
抗原
Human CDCD8
偶联物
形式
Liquid
保存条件
4° C, store in dark
运输条件
Wet ice
RRID
AB_2536505
产品详细信息
CD3 clone# S4.1, CD4 clone# S3.5, CD8 clone# 3B5
靶标信息
CD8 (Cluster of Differentiation 8) is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediate efficient cell-cell interactions within the immune system. The CD8 antigen acts as a co-receptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. CD8 is found on a T cell subset of normal cytotoxic/suppressor cells which make up approximately 20-35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer (NK) cells, subpopulations of peripheral blood null cells, thymocytes and bone marrow cells. The CD8 co-receptor functions as either a homodimer composed of two alpha chains, or as a disulfide-linked heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. The majority of CD8+ T cells express CD8 as a alpha/beta heterodimer. In HIV, the HIV-2 envelope glycoprotein binds CD8 alpha chain (but not the beta chain).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
