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产品信息
CL594-65058100T
应用
建议稀释比
已发表文章
产品规格
宿主/亚型
Rat
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
390
偶联物
CoraLite® 594
激发/发射光谱
593/614 nm
形式
Liquid
浓度
5 µL/Test
保存条件
4° C, store in dark
运输条件
Wet ice
靶标信息
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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