Invitrogen

CD34 Monoclonal Antibody (4H11), FITC, eBioscience™

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CD34 Antibody (11-0349-42) in Flow

Staining of normal human peripheral blood cells with Anti-Human CD45 APC (Product # 17-0459-42) and Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (left) or Anti-Human CD34 FITC (right). Total viable cells were used for analysis.

CD34 Antibody in Immunocytochemistry (ICC/IF)

Product Image Gallery

产品信息

11-0349-42

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

查看2篇已发表文章 2篇已发表文章

流式细胞分析 (Flow)

5 µL (0.5 µg)/test

查看67篇已发表文章 67篇已发表文章

其他PubMed (Misc)

查看2篇已发表文章 2篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

4H11

偶联物

FITC FITC FITC

激发/发射光谱

498/517 nm 查看光谱

形式

Liquid

浓度

5 µL/Test

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1518732

产品详细信息

Description: The 4H11 monoclonal antibody reacts with human CD34, also known as mucosialin. CD34 belongs to a protein family which also includes endoglycan and podocalyxin. Members of this family are single pass transmembrane proteins with a heavily glycosylated extracellular and N-terminal mucin domain. CD34 was first identified as an antigen expressed on hematopoietic progenitors, and has since been extensively used as a marker to isolate cells capable of hematopoietic cell engraftment. In spite of this, the function of CD34 remains unresolved. In addition to expression on hematopoietic progenitors, CD34 is expressed on some populations of mesenchymal stem cells, tumor cell lines, and by vascular endothelia in the adult. Epitopes of CD34 have been assigned to three classes (class I, II or III) based on their differential sensitivity to enzymatic cleavage by neuraminidase, chymopapain, or O-glycoprotease. According to this analysis, the 4H11 antibody belongs to class III, indicating that it reacts with a protein epitope.

Applications Reported: This 4H11 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This 4H11 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations. CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible. CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors. CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions. CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction. Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

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Celecoxib induces adipogenic differentiation of hemangioma-derived mesenchymal stem cells through the PPAR-γ pathway in vitro and in vivo.

Experimental and therapeutic medicine

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Mitochondrial oxidative phosphorylation is dispensable for survival of CD34⁺ chronic myeloid leukemia stem and progenitor cells.

Cell death & disease

Yan JS,Yang MY,Zhang XH,Luo CH,Du CK,Jiang Y,Dong XJ,Wang ZM,Yang LX,Li YD,Xia L,Lu Y

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Wed Apr 20 00:00:00 EDT 2022

Human placental mesenchymal stem cells regulate inflammation via the NF‑κB signaling pathway.

Experimental and therapeutic medicine

Liu Y,Zhang X,Hu Y,Kang M,Wu Y,Wang Y,Deng C

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Tue Nov 01 00:00:00 EDT 2022

Angiogenic stem cell delivery platform to augment post-infarction neovasculature and reverse ventricular remodeling.

Scientific reports

Shin HS,Thakore A,Tada Y,Pedroza AJ,Ikeda G,Chen IY,Chan D,Jaatinen KJ,Yajima S,Pfrender EM,Kawamura M,Yang PC,Wu JC,Appel EA,Fischbein MP,Woo Y,Shudo Y

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu Oct 20 00:00:00 EDT 2022

Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.

Cell discovery

Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue May 10 00:00:00 EDT 2022

Mechanical Compression by Simulating Orthodontic Tooth Movement in an In Vitro Model Modulates Phosphorylation of AKT and MAPKs via TLR4 in Human Periodontal Ligament Cells.

International journal of molecular sciences

Roth CE,Craveiro RB,Niederau C,Malyaran H,Neuss S,Jankowski J,Wolf M

11-0349-42 was used in Flow cytometry/Cell sorting to better understand the cell signaling downstream of key molecules involved in the process of sterile inflammation via TLR4.

Fri Jul 22 00:00:00 EDT 2022

LIM Mineralization Protein-1 Enhances the Committed Differentiation of Dental Pulp Stem Cells through the ERK1/2 and p38 MAPK Pathways and BMP Signaling.

International journal of medical sciences

Mu R,Chen B,Bi B,Yu H,Liu J,Li J,He M,Rong L,Liu B,Liu K,Zhu L,Shi X,Shuai Y,Jin L

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Mon Aug 08 00:00:00 EDT 2022

Eltrombopag increases the hematopoietic supporting ability of mesenchymal stem/stromal cells.

Therapeutic advances in hematology

Muntión S,Preciado S,Sánchez-Luis E,Corchete L,Díez-Campelo M,Osugui L,Martí-Chillón GJ,Vidriales MB,Navarro-Bailón A,De Las Rivas J,Sánchez-Guijo F

11-0349-42 was used in Flow cytometry/Cell sorting to suggest that further studies on the effects of EP on MSCs from patients with aplastic anemia are warranted.

Wed Jan 11 00:00:00 EST 2023

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia.

The Journal of experimental medicine

Louka E,Povinelli B,Rodriguez-Meira A,Buck G,Wen WX,Wang G,Sousos N,Ashley N,Hamblin A,Booth CAG,Roy A,Elliott N,Iskander D,de la Fuente J,Fordham N,O'Byrne S,Inglott S,Norfo R,Salio M,Thongjuea S,Rao A,Roberts I,Mead AJ

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Mon Feb 01 00:00:00 EST 2021

VAP-PLGA microspheres (VAP-PLGA) promote adipose-derived stem cells (ADSCs)-induced wound healing in chronic skin ulcers in mice via PI3K/Akt/HIF-1α pathway.

Bioengineered

Jiang W,Zhang J,Zhang X,Fan C,Huang J

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed Dec 01 00:00:00 EST 2021

Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway.

Frontiers in cardiovascular medicine

Zhang H,Zhou H,Yuan J,Nan Y,Liu J

11-0349-42 was used in Flow cytometry/Cell sorting to determine the regulatory mechanism of ischemic angiogenesis and to verify the role of GABBR2 in angiogenesis.

Tue Aug 24 00:00:00 EDT 2021

Endothelial GABBR2 Regulates Post-ischemic Angiogenesis by Inhibiting the Glycolysis Pathway.

Frontiers in cardiovascular medicine

Zhang H,Zhou H,Yuan J,Nan Y,Liu J

11-0349-42 was used in Flow cytometry/Cell sorting to determine the regulatory mechanism of ischemic angiogenesis and to verify the role of GABBR2 in angiogenesis.

Tue Aug 24 00:00:00 EDT 2021

Modeling of endothelial cell dysfunction using human induced pluripotent stem cells derived from patients with end-stage renal disease.

Kidney research and clinical practice

Kim KW,Shin YJ,Kim BM,Cui S,Ko EJ,Lim SW,Yang CW,Chung BH

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Immunocytochemistry

Wed Dec 01 00:00:00 EST 2021

TRPA1 triggers hyperalgesia and inflammation after tooth bleaching.

Scientific reports

Chen C,Huang X,Zhu W,Ding C,Huang P,Li R

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Aug 31 00:00:00 EDT 2021

Development, characterization, and hematopoietic differentiation of Griscelli syndrome type 2 induced pluripotent stem cells.

Stem cell research & therapy

Güney-Esken G,Erol ÖD,Pervin B,Gürhan Sevinç G,Önder T,Bilgiç E,Korkusuz P,Günel-Özcan A,Uçkan-Çetinkaya D,Aerts-Kaya F

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

Targeting the epichaperome as an effective precision medicine approach in a novel PML-SYK fusion acute myeloid leukemia.

NPJ precision oncology

Sugita M,Wilkes DC,Bareja R,Eng KW,Nataraj S,Jimenez-Flores RA,Yan L,De Leon JP,Croyle JA,Kaner J,Merugu S,Sharma S,MacDonald TY,Noorzad Z,Panchal P,Pancirer D,Cheng S,Xiang JZ,Olson L,Van Besien K,Rickman DS,Mathew S,Tam W,Rubin MA,Beltran H,Sboner A,Hassane DC,Chiosis G,Elemento O,Roboz GJ,Mosquera JM,Guzman ML

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed May 26 00:00:00 EDT 2021

Wip1 regulates the immunomodulatory effects of murine mesenchymal stem cells in type 1 diabetes mellitus via targeting IFN-α/BST2.

Cell death discovery

Zhou N,Liu W,Zhang W,Liu Y,Li X,Wang Y,Zheng R,Zhang Y

11-0349-42 was used in Flow Cytometry to reveal Wip1 affects MSCs immunomodulation by regulating the expression of IFN-α/BST2.

Fri Oct 29 00:00:00 EDT 2021

Evaluation of glycolytic rates in human hematopoietic stem/progenitor cells after target gene depletion.

STAR protocols

Qing Y,Gao L,Han L,Su R,Chen J

11-0349-42 was used in Flow cytometry/Cell sorting to show that this protocol can be applied to evaluate potential aerobic glycolysis gene targets for cancer therapy.

Fri Jun 18 00:00:00 EDT 2021

Targeting aberrant DNA methylation in mesenchymal stromal cells as a treatment for myeloma bone disease.

Nature communications

Garcia-Gomez A,Li T,de la Calle-Fabregat C,Rodríguez-Ubreva J,Ciudad L,Català-Moll F,Godoy-Tena G,Martín-Sánchez M,San-Segundo L,Muntión S,Morales X,Ortiz-de-Solórzano C,Oyarzabal J,San José-Enériz E,Esteller M,Agirre X,Prosper F,Garayoa M,Ballestar E

11-0349-42 was used in Flow Cytometry to study the efficacy of targeting methylation in myeloma bone disease.

Mon Jan 18 00:00:00 EST 2021

Phenotypic and functional characterization of synovial fluid-derived fibroblast-like synoviocytes in rheumatoid arthritis.

Scientific reports

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Fri Nov 12 00:00:00 EST 2021

Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.

Cancer cell

Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J

11-0349-42 was used in Flow Cytometry to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.

Mon Jul 13 00:00:00 EDT 2020

Differentiation Potential of Early- and Late-Passage Adipose-Derived Mesenchymal Stem Cells Cultured under Hypoxia and Normoxia.

Stem cells international

Zhao AG,Shah K,Freitag J,Cromer B,Sumer H

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Oct 06 00:00:00 EDT 2020

Resveratrol rescues TNF‑α‑induced inhibition of osteogenesis in human periodontal ligament stem cells via the ERK1/2 pathway.

Molecular medicine reports

Yuan J,Wang X,Ma D,Gao H,Zheng D,Zhang J

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

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High expression of endothelial progenitor cell-induced angiogenic markers is associated with bile acid levels in HCC.

Oncology letters

Chen JL,Wang L,Li R,Jiao YF,Yu WF

11-0349 was used in Flow cytometry/Cell sorting to investigate the factors influencing the number of EPCs and circulating progenitor cells (CPCs), as well as the expression levels of vascular endothelial growth factor receptor 2 (VEGFR-2) and CD34, in patients with hepatocellular carcinoma.

Tue Sep 01 00:00:00 EDT 2020

Genome-Wide Transcriptional Regulation of the Long Non-coding RNA Steroid Receptor RNA Activator in Human Erythroblasts.

Frontiers in genetics

Sawaengdee W,Cui K,Zhao K,Hongeng S,Fucharoen S,Wongtrakoongate P

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Chemerin enhances the adhesion and migration of human endothelial progenitor cells and increases lipid accumulation in mice with atherosclerosis.

Lipids in health and disease

Jia J,Yu F,Xiong Y,Wei W,Ma H,Nisi F,Song X,Yang L,Wang D,Yuan G,Zhou H

11-0349 was used in Flow cytometry/Cell sorting to explore the effects of chemerin on the functions of human endothelial progenitor cells and to investigate its role in lipid accumulation in ApoE-knockout mice.

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Chemerin enhances the adhesion and migration of human endothelial progenitor cells and increases lipid accumulation in mice with atherosclerosis.

Lipids in health and disease

Jia J,Yu F,Xiong Y,Wei W,Ma H,Nisi F,Song X,Yang L,Wang D,Yuan G,Zhou H

Sun Sep 20 00:00:00 EDT 2020

Apoptotic bodies derived from mesenchymal stem cells promote cutaneous wound healing via regulating the functions of macrophages.

Stem cell research & therapy

Liu J,Qiu X,Lv Y,Zheng C,Dong Y,Dou G,Zhu B,Liu A,Wang W,Zhou J,Liu S,Liu S,Gao B,Jin Y

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Fri Nov 27 00:00:00 EST 2020

Biological Therapy in Inflammatory Bowel Disease Patients Partly Restores Intestinal Innate Lymphoid Cell Subtype Equilibrium.

Frontiers in immunology

Creyns B,Jacobs I,Verstockt B,Cremer J,Ballet V,Vandecasteele R,Vanuytsel T,Ferrante M,Vermeire S,Van Assche G,Ceuppens JL,Breynaert C

11-0349 was used in Flow cytometry/Cell sorting to study the impact of biological treatment on innate lymphoid cells in Crohn disease and ulcerative colitis.

Mon Apr 12 00:00:00 EDT 2021

The downregulated membrane expression of CD18 in CD34⁺ cells defines a primitive population of human hematopoietic stem cells.

Stem cell research & therapy

Mesa-Núñez C,Leon-Rico D,Aldea M,Damián C,Sanchez-Baltasar R,Sanchez R,Alberquilla O,Segovia JC,Bueren JA,Almarza E

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Tue Apr 28 00:00:00 EDT 2020

CD62L Is a Functional and Phenotypic Marker for Circulating Innate Lymphoid Cell Precursors.

Journal of immunology (Baltimore, Md. : 1950)

Bar-Ephraim YE,Koning JJ,Burniol Ruiz E,Konijn T,Mourits VP,Lakeman KA,Boon L,Bögels M,van Maanen JP,Den Haan JMM,van Egmond M,Bouma G,Reijmers RM,Mebius RE

11-0349-42 was used in Flow Cytometry to demonstrate that CD62L not only serves as a functional marker of ILCP, but has potential to be used in the clinic as a diagnostic marker in inflammatory disorders.

Tue Jan 01 00:00:00 EST 2019

Therapeutic Effects of Human Urine-Derived Stem Cells in a Rat Model of Cisplatin-Induced Acute Kidney Injury In Vivo and In Vitro.

Stem cells international

Sun B,Luo X,Yang C,Liu P,Yang Y,Dong X,Yang Z,Xu J,Zhang Y,Li L

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu May 13 00:00:00 EDT 2021

TGF‑β induces periodontal ligament stem cell senescence through increase of ROS production.

Molecular medicine reports

Fan C,Ji Q,Zhang C,Xu S,Sun H,Li Z

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment.

Biology open

Sun Y,Ren Y,Yang F,He Y,Liang S,Guan L,Cheng F,Liu Y,Lin J

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu May 02 00:00:00 EDT 2019

High-yield isolation of menstrual blood-derived endometrial stem cells by direct red blood cell lysis treatment.

Biology open

Sun Y,Ren Y,Yang F,He Y,Liang S,Guan L,Cheng F,Liu Y,Lin J

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu May 02 00:00:00 EDT 2019

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis.

Nature communications

Kidoya H,Muramatsu F,Shimamura T,Jia W,Satoh T,Hayashi Y,Naito H,Kunisaki Y,Arai F,Seki M,Suzuki Y,Osawa T,Akira S,Takakura N

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed Mar 06 00:00:00 EST 2019

Visfatin Mediates Malignant Behaviors through Adipose-Derived Stem Cells Intermediary in Breast Cancer.

Cancers

Huang JY,Wang YY,Lo S,Tseng LM,Chen DR,Wu YC,Hou MF,Yuan SF

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Fri Dec 20 00:00:00 EST 2019

Efficient gene transfer into T lymphocytes by fiber-modified human adenovirus 5.

BMC biotechnology

Lv Y,Xiao FJ,Wang Y,Zou XH,Wang H,Wang HY,Wang LS,Lu ZZ

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed Apr 24 00:00:00 EDT 2019

Effect of cell culture density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation.

Scientific reports

Noda S,Kawashima N,Yamamoto M,Hashimoto K,Nara K,Sekiya I,Okiji T

11-0349-42 was used in Flow Cytometry to analyze the effect of cell culture condition, especially dense culture condition, on the property and differentiation pathway of dental pulp stem cells.

Mon Apr 01 00:00:00 EDT 2019

The suppressive effects of miR-508-5p on the odontogenic differentiation of human dental pulp stem cells by targeting glycoprotein non-metastatic melanomal protein B.

Stem cell research & therapy

Liu F,Wang X,Yang Y,Hu R,Wang W,Wang Y

11-0349-42 was used in Flow cytometry/Cell sorting to investigate the effects of miR-508-5p on the glycoprotein non-metastatic melanomal protein B expression and the odontogenic differentiation of human dental pulp stem cells.

Tue Jan 22 00:00:00 EST 2019

A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.

Developmental cell

Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Mon Feb 05 00:00:00 EST 2018

Isolation and characterization of stem cells from differentially degenerated human lumbar zygapophyseal articular cartilage.

Molecular medicine reports

Xiao L,Xu S,Wang X,Jin Z,Wang J,Yang B,Xu H

11-0349 was used in Flow cytometry/Cell sorting to show stem cells with multilineage differentiation potential and clonal properties were identified in human LZAC, and these characteristics were more prominent in mildly degenerated as compared with severely degenerated articular cartilage.

Sat Dec 01 00:00:00 EST 2018

Human umbilical cord-derived mesenchymal stem cells ameliorate the enteropathy of food allergies in mice.

Experimental and therapeutic medicine

Yan N,Xu J,Zhao C,Wu Y,Gao F,Li C,Zhou W,Xiao T,Zhou X,Shao Q,Xia S

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Sat Dec 01 00:00:00 EST 2018

BNIP3/Bcl-2-mediated apoptosis induced by cyclic tensile stretch in human cartilage endplate-derived stem cells.

Experimental and therapeutic medicine

Yuan C,Pu L,He Z,Wang J

11-0349-42 was used in Flow Cytometry to investigate the molecular mechanisms of cyclic stretch-induced apoptosis in human intervertebral disc cartilage endplate-derived stem cells (CESCs).

Mon Jan 01 00:00:00 EST 2018

Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome.

Stem cell research & therapy

Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

11-0349 was used in Flow cytometry/Cell sorting to investigate whether in vitro mechanopriming of human mesenchymal stromal cells can be administered to predictively and significantly improve in vivo haematopoietic recovery after irradiation injury.

Wed Oct 24 00:00:00 EDT 2018

Improving hematopoietic recovery through modeling and modulation of the mesenchymal stromal cell secretome.

Stem cell research & therapy

Liu FD,Tam K,Pishesha N,Poon Z,Van Vliet KJ

Wed Oct 24 00:00:00 EDT 2018

Exosomes secreted by adipose-derived mesenchymal stem cells regulate type I collagen metabolism in fibroblasts from women with stress urinary incontinence.

Stem cell research & therapy

Liu X,Wang S,Wu S,Hao Q,Li Y,Guo Z,Wang W

11-0349 was used in Flow cytometry/Cell sorting to evaluate the effects of exomes secreted by adipose-derived mesenchymal stem cells on collagen metabolism in cultured fibroblasts from women with stress urinary incontinence.

Wed Jun 13 00:00:00 EDT 2018

Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.

Nature communications

Ackermann M,Kempf H,Hetzel M,Hesse C,Hashtchin AR,Brinkert K,Schott JW,Haake K,Kühnel MP,Glage S,Figueiredo C,Jonigk D,Sewald K,Schambach A,Wronski S,Moritz T,Martin U,Zweigerdt R,Munder A,Lachmann N

11-0349 was used in Flow cytometry/Cell sorting to develop a novel, cell-based treatment strategy to target bacterial airway infections.

Fri Nov 30 00:00:00 EST 2018

Combined inhibition of β-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo.

Leukemia

Zhou H,Mak PY,Mu H,Mak DH,Zeng Z,Cortes J,Liu Q,Andreeff M,Carter BZ

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Miscellaneous

Sun Oct 01 00:00:00 EDT 2017

Activation of KLF1 Enhances the Differentiation and Maturation of Red Blood Cells from Human Pluripotent Stem Cells.

Stem cells (Dayton, Ohio)

Yang CT,Ma R,Axton RA,Jackson M,Taylor AH,Fidanza A,Marenah L,Frayne J,Mountford JC,Forrester LM

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

A high-yield isolation and enrichment strategy for human lung microvascular endothelial cells.

Pulmonary circulation

Gaskill C,Majka SM

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

Vitamin C plus hydrogel facilitates bone marrow stromal cell-mediated endometrium regeneration in rats.

Stem cell research & therapy

Yang H,Wu S,Feng R,Huang J,Liu L,Liu F,Chen Y

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Nov 21 00:00:00 EST 2017

Human umbilical cord mesenchymal stem cells improve the reserve function of perimenopausal ovary via a paracrine mechanism.

Stem cell research & therapy

Li J,Mao Q,He J,She H,Zhang Z,Yin C

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu Mar 09 00:00:00 EST 2017

Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB-Independent Tissue-Resident Macrophages.

Stem cell reports

Buchrieser J,James W,Moore MD

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Feb 14 00:00:00 EST 2017

Feasibility of placenta-derived mesenchymal stem cells as a tool for studying pregnancy-related disorders.

Scientific reports

Fuchi N,Miura K,Doi H,Li TS,Masuzaki H

11-0349 was used in Flow cytometry/Cell sorting to evaluate the feasibility of using placenta-derived mesenchymal stem cells as a tool to study pregnancy related disorders.

Wed Apr 12 00:00:00 EDT 2017

Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.

Stem cells translational medicine

Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a.

Journal of cell science

Liang X,Zhang L,Wang S,Han Q,Zhao RC

11-0349 was used in Flow cytometry/Cell sorting to indicate that adMSC-Exo can transfer miR-125a to endothelial cells and promote angiogenesis by repressing DLL4.

Wed Jun 01 00:00:00 EDT 2016

A Member of the Nuclear Receptor Superfamily, Designated as NR2F2, Supports the Self-Renewal Capacity and Pluripotency of Human Bone Marrow-Derived Mesenchymal Stem Cells.

Stem cells international

Zhu N,Wang H,Wang B,Wei J,Shan W,Feng J,Huang H

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Jan 19 00:00:00 EST 2016

Repurposing Treprostinil for Enhancing Hematopoietic Progenitor Cell Transplantation.

Molecular pharmacology

Kazemi Z,Bergmayr C,Prchal-Murphy M,Javaheri T,Themanns M,Pham HT,Strohmaier W,Sexl V,Freissmuth M,Zebedin-Brandl E

11-0349 was used in Flow cytometry/Cell sorting to assess whether treprostinil, a prostacyclin analog, could be repurposed to improve hematopoietic stem cell transplantation.

Wed Jun 01 00:00:00 EDT 2016

Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients.

PloS one

Muntión S,Ramos TL,Diez-Campelo M,Rosón B,Sánchez-Abarca LI,Misiewicz-Krzeminska I,Preciado S,Sarasquete ME,de Las Rivas J,González M,Sánchez-Guijo F,Del Cañizo MC

Tue Jul 12 00:00:00 EDT 2016

Microvesicles from Mesenchymal Stromal Cells Are Involved in HPC-Microenvironment Crosstalk in Myelodysplastic Patients.

PloS one

Muntión S,Ramos TL,Diez-Campelo M,Rosón B,Sánchez-Abarca LI,Misiewicz-Krzeminska I,Preciado S,Sarasquete ME,de Las Rivas J,González M,Sánchez-Guijo F,Del Cañizo MC

Tue Jul 12 00:00:00 EDT 2016

A Simplified Method for the Aspiration of Bone Marrow from Patients Undergoing Hip and Knee Joint Replacement for Isolating Mesenchymal Stem Cells and In Vitro Chondrogenesis.

Bone marrow research

Juneja SC,Viswanathan S,Ganguly M,Veillette C

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Fri Apr 08 00:00:00 EDT 2016

CRISPR/Cas9-based genetic correction for recessive dystrophic epidermolysis bullosa.

NPJ Regenerative medicine

Webber BR,Osborn MJ,McElroy AN,Twaroski K,Lonetree CL,DeFeo AP,Xia L,Eide C,Lees CJ,McElmurry RT,Riddle MJ,Kim CJ,Patel DD,Blazar BR,Tolar J

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Wed Sep 30 00:00:00 EDT 2020

Potency of umbilical cord blood- and Wharton's jelly-derived mesenchymal stem cells for scarless wound healing.

Scientific reports

Doi H,Kitajima Y,Luo L,Yan C,Tateishi S,Ono Y,Urata Y,Goto S,Mori R,Masuzaki H,Shimokawa I,Hirano A,Li TS

11-0349 was used in Flow cytometry/Cell sorting to determine that umbilical cord blood offers a potential source of MSCs for therapeutic scarless wound healing.

Tue Jan 05 00:00:00 EST 2016

MIF Plays a Key Role in Regulating Tissue-Specific Chondro-Osteogenic Differentiation Fate of Human Cartilage Endplate Stem Cells under Hypoxia.

Stem cell reports

Yao Y,Deng Q,Song W,Zhang H,Li Y,Yang Y,Fan X,Liu M,Shang J,Sun C,Tang Y,Jin X,Liu H,Huang B,Zhou Y

11-0349 was used in Flow cytometry/Cell sorting to show MIF plays a role in regulating the differentiation fate of human cartilage endplate stem cells under hypoxia.

Tue Aug 09 00:00:00 EDT 2016

Focal Adhesion Kinase Signaling Mediated the Enhancement of Osteogenesis of Human Mesenchymal Stem Cells Induced by Extracorporeal Shockwave.

Scientific reports

Hu J,Liao H,Ma Z,Chen H,Huang Z,Zhang Y,Yu M,Chen Y,Xu J

11-0349 was used in Flow cytometry/Cell sorting to investigate the underlying mechanisms of osteogenic effects of bone marrow mesenchymal stem cells induced by extracorporeal shockwave.

Thu Feb 11 00:00:00 EST 2016

Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.

American journal of physiology. Cell physiology

Hänggi P,Telezhkin V,Kemp PJ,Schmugge M,Gassmann M,Goede JS,Speer O,Bogdanova A

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Mon Jun 15 00:00:00 EDT 2015

Differences in the Osteogenic Differentiation Capacity of Omental Adipose-Derived Stem Cells in Obese Patients With and Without Metabolic Syndrome.

Endocrinology

Oliva-Olivera W,Leiva Gea A,Lhamyani S,Coín-Aragüez L,Alcaide Torres J,Bernal-López MR,García-Luna PP,Morales Conde S,Fernández-Veledo S,El Bekay R,Tinahones FJ

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Tue Dec 01 00:00:00 EST 2015

Single-cell mass cytometry reveals intracellular survival/proliferative signaling in FLT3-ITD-mutated AML stem/progenitor cells.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Han L,Qiu P,Zeng Z,Jorgensen JL,Mak DH,Burks JK,Schober W,McQueen TJ,Cortes J,Tanner SD,Roboz GJ,Kantarjian HM,Kornblau SM,Guzman ML,Andreeff M,Konopleva M

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Miscellaneous

Wed Apr 01 00:00:00 EDT 2015

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model.

Stem cell research & therapy

Zhou F,Gao S,Wang L,Sun C,Chen L,Yuan P,Zhao H,Yi Y,Qin Y,Dong Z,Cao L,Ren H,Zhu L,Li Q,Lu B,Liang A,Xu GT,Zhu H,Gao Z,Ma J,Xu J,Chen X

11-0349 was used in Flow cytometry/Cell sorting to demonstrate human adipose derived stem cell (hDAC) intervention with MCAO mice could apparently ameliorate stroke symptoms by direct cell replacement, enhanced immnunosuppression and increasing the viability of endogenous neurons.

Sat May 09 00:00:00 EDT 2015

Reprogramming human endothelial cells to haematopoietic cells requires vascular induction.

Nature

Sandler VM,Lis R,Liu Y,Kedem A,James D,Elemento O,Butler JM,Scandura JM,Rafii S

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu Jul 17 00:00:00 EDT 2014

JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo.

Blood

Gallipoli P,Cook A,Rhodes S,Hopcroft L,Wheadon H,Whetton AD,Jørgensen HG,Bhatia R,Holyoake TL

Published figure using CD34 monoclonal antibody (Product # 11-0349-42) in Flow Cytometry

Thu Aug 28 00:00:00 EDT 2014

A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.

Arthritis & rheumatology (Hoboken, N.J.)

Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L

11-0349 was used in Flow cytometry/Cell sorting to highlight a previously unrecognised CD8+ T cell/IFNγ/IDO axis that mediates the therapeutic effects of allogeneic MSCs in lupus patients.

Fri Aug 01 00:00:00 EDT 2014

Microvesicles derived from human umbilical cord Wharton's jelly mesenchymal stem cells attenuate bladder tumor cell growth in vitro and in vivo.

PloS one

Wu S,Ju GQ,Du T,Zhu YJ,Liu GH

11-0349 was used in Flow cytometry/Cell sorting to investigate microvesicles derived from human umbilical cord mesenchymal stem cells, and their ability to attenuate bladder tumour cell growth.