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产品信息
PA5-119034
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein Cluster Of Differentiation 36. The antigen corresponds to amino acid range 187-428 of the target protein.
偶联物
形式
Liquid
浓度
0.32 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2903534
靶标信息
CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. CD36 is also implicated in the pathogenesis of malaria. The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. It binds to collagen, thrombospondin, anionic phospholipids, and oxidized LDL, and directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. Diseases associated with CD36 include Platelet Glycoprotein IV Deficiency and Coronary Heart Disease 7.
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生物信息学
蛋白别名: CD36; CD36 antigen (collagen type I receptor, thrombospondin receptor); CD36 molecule (thrombospondin receptor); cluster determinant 36; FAT; Fatty acid translocase; Glycoprotein IIIb; GPIIIB; GPIV; Leukocyte differentiation antigen CD36; PAS IV; PAS-4; PAS-4 protein; Platelet collagen receptor; Platelet glycoprotein 4; Platelet glycoprotein IV; scavenger receptor class B, member 3; SR-B3; Thrombospondin receptor
基因别名: BDPLT10; CD36; CHDS7; FAT; GP3B; GP4; GPIV; PASIV; SCARB3
UniProt ID: (Human) P16671
Entrez Gene ID: (Human) 948
low-density lipoprotein receptor activity
protein binding
high-density lipoprotein particle binding
lipid binding
low-density lipoprotein particle binding
transforming growth factor beta binding
thrombospondin receptor activity
lipoteichoic acid receptor activity
lipoprotein particle binding
membrane trafficking regulatory protein
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cell-matrix adhesion
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
platelet degranulation
MyD88-dependent toll-like receptor signaling pathway
lipid metabolic process
receptor-mediated endocytosis
phagocytosis, recognition
immune response
cell adhesion
cell surface receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
nitric oxide mediated signal transduction
blood coagulation
positive regulation of macrophage derived foam cell differentiation
positive regulation of cholesterol storage
lipid storage
cGMP-mediated signaling
positive regulation of blood coagulation
intestinal cholesterol absorption
cholesterol transport
receptor internalization
positive regulation of interleukin-12 production
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
response to lipid
triglyceride transport
plasma lipoprotein particle clearance
low-density lipoprotein particle clearance
response to stilbenoid
toll-like receptor TLR6:TLR2 signaling pathway
lipoprotein transport
negative regulation of transcription factor import into nucleus
positive regulation of I-kappaB kinase/NF-kappaB signaling
apoptotic cell clearance
negative regulation of growth of symbiont in host
long-chain fatty acid import
interleukin-1 beta secretion
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-positive bacterium
intestinal absorption
sensory perception of taste
low-density lipoprotein particle mediated signaling
positive regulation of phagocytosis, engulfment
positive regulation of macrophage cytokine production
positive regulation of ERK1 and ERK2 cascade
cholesterol import
response to fatty acid
response to linoleic acid
cellular response to lipopolysaccharide
cellular response to lipoteichoic acid
cellular response to low-density lipoprotein particle stimulus
cellular response to hydroperoxide
cellular response to diacyl bacterial lipopeptide
positive regulation of NLRP3 inflammasome complex assembly
amyloid fibril formation
regulation of removal of superoxide radicals
positive regulation of blood microparticle formation
positive regulation of reactive oxygen species metabolic process
regulation of energy homeostasis
