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NeoBiotechnologies
CD38 (ADP Ribosyl Cyclase I) Recombinant Rabbit Monoclonal Antibody (CD38/8335R)
产品信息
952-RBM18-P1
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
CD38/8335R
抗原
Recombinant fragment (around aa 200-300) of human CD38.
偶联物
形式
Liquid
浓度
200 µg/mL
纯化类型
Protein A/G
保存液
PBS with 0.05% BSA
内含物
0.05% sodium azide
保存条件
4° C
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Positive Control:Human tonsil or spleen. Raji cells.
Cellular Location: Cell Surface. Cytoplasm.
靶标信息
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPR hydrolase 1; CD38; CD38 antigen (p45); CD38 antigen p45; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; NAD+ nucleosidase; T10
基因别名: ADPRC 1; ADPRC1; CD38
UniProt ID: (Human) P28907
Entrez Gene ID: (Human) 952
response to hypoxia
signal transduction
positive regulation of cytosolic calcium ion concentration
female pregnancy
positive regulation of cell growth
positive regulation of B cell proliferation
positive regulation of insulin secretion
response to estradiol
response to retinoic acid
response to progesterone
response to hydroperoxide
response to drug
negative regulation of apoptotic process
negative regulation of bone resorption
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of vasoconstriction
B cell receptor signaling pathway
long term synaptic depression
response to interleukin-1
apoptotic signaling pathway
