Invitrogen

CD38 Monoclonal Antibody (HIT2), APC-Cyanine5.5

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CD38 Antibody (MHCD3819) in Flow

Immunity 2020 - Figure 6 Polyreactivity Is Inherent to Naive B Cells Selected into the Broadly Neutralizing Response (A) Proportion of mAbs generated from total naive B cells and MBCs and from influenza stalk domain-binding germline B cells, MBCs, and plasmablasts that were polyreactive. (B and C) Binding AUC of polyreactive mAbs or the corresponding germline-reverted mAbs binding to A/California/7/2009 (n = 12) and A/Bris... View More

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产品信息

MHCD3819

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

Assay-Dependent

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

抗原

Human CD38

偶联物

APC-Cyanine5.5 APC-Cyanine5.5 APC-Cyanine5.5

激发/发射光谱

656/700 nm 查看光谱

形式

Liquid

纯化类型

purified

保存液

PBS with BSA, sucrose

内含物

0.1% sodium azide

保存条件

4° C, store in dark

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_10371760

靶标信息

CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

Analyte Specific Reagent

How to use the Panel Builder

Watch the video to learn how to use the Invitrogen Flow Cytometry Panel Builder to build your next flow cytometry panel in 5 easy steps.

Product References

Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia.

Immunity

Kreutmair S,Unger S,Núñez NG,Ingelfinger F,Alberti C,De Feo D,Krishnarajah S,Kauffmann M,Friebel E,Babaei S,Gaborit B,Lutz M,Jurado NP,Malek NP,Goepel S,Rosenberger P,Häberle HA,Ayoub I,Al-Hajj S,Nilsson J,Claassen M,Liblau R,Martin-Blondel G,Bitzer M,Roquilly A,Becher B

MHCD3819 was used in Flow Cytometry to identify pathological immune signatures suggestive of T cell exhaustion unique to COVID-19 infection.

Tue Jul 13 00:00:00 EDT 2021

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.

Immunity

Guthmiller JJ,Lan LY,Fernández-Quintero ML,Han J,Utset HA,Bitar DJ,Hamel NJ,Stovicek O,Li L,Tepora M,Henry C,Neu KE,Dugan HL,Borowska MT,Chen YQ,Liu STH,Stamper CT,Zheng NY,Huang M,Palm AE,García-Sastre A,Nachbagauer R,Palese P,Coughlan L,Krammer F,Ward AB,Liedl KR,Wilson PC

MHCD3819 was used in Flow Cytometry to reveal that polyreactivity is a beneficial feature of antibodies targeting conserved epitopes.

Tue Dec 15 00:00:00 EST 2020

Polyreactive Broadly Neutralizing B cells Are Selected to Provide Defense against Pandemic Threat Influenza Viruses.

Immunity

MHCD3819 was used in Flow Cytometry to reveal that polyreactivity is a beneficial feature of antibodies targeting conserved epitopes.

Tue Dec 15 00:00:00 EST 2020

Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies.

JCI insight

Shah HB,Smith K,Scott EJ,Larabee JL,James JA,Ballard JD,Lang ML

MHCD3819 was used in Flow Cytometry to study memory B cell function following C. difficile infection.

Thu Aug 20 00:00:00 EDT 2020

Human C. difficile toxin-specific memory B cell repertoires encode poorly neutralizing antibodies.

JCI insight

Shah HB,Smith K,Scott EJ,Larabee JL,James JA,Ballard JD,Lang ML

MHCD3819 was used in Flow Cytometry to study memory B cell function following C. difficile infection.

Thu Aug 20 00:00:00 EDT 2020

Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication.

Infection and immunity

Sevigny LM,Booth BJ,Rowley KJ,Leav BA,Cheslock PS,Garrity KA,Sloan SE,Thomas W,Babcock GJ,Wang Y

MHCD3819 was used in Flow cytometry/Cell sorting to report on how the discovery of a specific and potent human neutralizing antibody against diphtheria toxin holds promise as a potential therapeutic.

Fri Nov 01 00:00:00 EDT 2013

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen.

Nature protocols

Smith K,Garman L,Wrammert J,Zheng NY,Capra JD,Ahmed R,Wilson PC

MHCD3819 was used in Flow cytometry/Cell sorting to develop a protocol for the production of antigen-specific human monoclonal antibodies.

Wed Apr 08 00:00:00 EDT 2009

生物信息学

蛋白别名: 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADPRC 1; cADPR hydrolase 1; CD38; CD38 antigen (p45); CD38 antigen p45; cluster of differentiation 38; Cyclic ADP-ribose hydrolase 1; ecto-nicotinamide adenine dinucleotide glycohydrolase; NAD(+) nucleosidase; NAD+ nucleosidase; T10

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基因别名: ADPRC 1; ADPRC1; CD38

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UniProt ID: (Human) P28907

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Entrez Gene ID: (Human) 952

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功能

NAD+ nucleosidase activity transferase activity phosphorus-oxygen lyase activity NAD(P)+ nucleosidase activity cyclase lyase metabolite interconversion enzyme

参与通路