Invitrogen

CD4 Monoclonal Antibody (RPA-T4), PE-Cyanine5, eBioscience™

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CD4 Antibody (15-0049-42) in Flow

Staining of normal human peripheral blood cells with Mouse IgG1 Isotype Control PE-Cyanine5 (Product # 15-4714-81) (open histogram) or Anti-Human CD4 PE-Cyanine5 (filled histogram).Cells in the lymphocyte gate were used for analysis.

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产品信息

15-0049-42

应用

建议稀释比

已发表文章

免疫细胞化学 (ICC/IF)

查看1篇已发表文章 1篇已发表文章

流式细胞分析 (Flow)

5 µL (0.25 µg)/test

查看50篇已发表文章 50篇已发表文章

产品规格

种属反应

Human

已发表种属

Human, Mouse

宿主/亚型

Mouse / IgG1, kappa

分类

Monoclonal

类型

Antibody

克隆号

RPA-T4

偶联物

PE-Cyanine5 PE-Cyanine5 PE-Cyanine5

激发/发射光谱

568/666 nm 查看光谱

形式

Liquid

浓度

5 µL/Test

纯化类型

Affinity chromatography

保存液

PBS, pH 7.2, with 0.2% BSA

内含物

0.09% sodium azide

保存条件

4° C, store in dark, DO NOT FREEZE!

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1582251

产品详细信息

Description: The RPA-T4 monoclonal antibody reacts with human CD4, a 59 kDa cell surface receptor expressed by a majority of thymocytes, subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). RPA-T4 blocks HIV binding and mixed lymphocyte reaction. The RPA-T4 antibody recognizes a different epitope than the OKT4 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes.

Applications Reported: The RPA-T4 antibody has been reported for use in flow cytometric analysis.

Applications Tested: This RPA-T4 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.25 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.

Light sensitivity: This tandem dye is sensitive photo-induced oxidation. Please protect this vial and stained samples from light.

Fixation: Samples can be stored in IC Fixation Buffer (Product # 00-822-49) (100 µL cell sample + 100 µL IC Fixation Buffer) or 1-step Fix/Lyse Solution (Product # 00-5333-54) for up to 3 days in the dark at 4°C with minimal impact on brightness and FRET efficiency/compensation. Some generalizations regarding fluorophore performance after fixation can be made, but clone specific performance should be determined empirically.

Excitation: 488-561 nm; Emission: 667 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.

Filtration: 0.2 µm post-manufacturing filtered.

靶标信息

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Product References

Cathepsin S inhibition in dendritic cells prevents Th17 cell differentiation in perivascular adipose tissues following vascular injury in diabetic rats.

Journal of biochemical and molecular toxicology

Peng H,Lv Y,Li C,Cheng Z,He S,Wang C,Liu J

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Fri Sep 01 00:00:00 EDT 2023

Rapamycin improves Graves' orbitopathy by suppressing CD4+ cytotoxic T lymphocytes.

JCI insight

Zhang M,Chong KK,Chen ZY,Guo H,Liu YF,Kang YY,Li YJ,Shi TT,Lai KK,He MQ,Ye K,Kahaly GJ,Shi BY,Wang Y

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Wed Feb 08 00:00:00 EST 2023

Single-cell RNA sequencing reveals the molecular features of peripheral blood immune cells in children, adults and centenarians.

Frontiers in immunology

Zhong J,Ding R,Jiang H,Li L,Wan J,Feng X,Chen M,Peng L,Li X,Lin J,Yang H,Wang M,Li Q,Chen Q

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Mon Jan 30 00:00:00 EST 2023

Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity.

Nature communications

McEvoy CM,Murphy JM,Zhang L,Clotet-Freixas S,Mathews JA,An J,Karimzadeh M,Pouyabahar D,Su S,Zaslaver O,Röst H,Arambewela R,Liu LY,Zhang S,Lawson KA,Finelli A,Wang B,MacParland SA,Bader GD,Konvalinka A,Crome SQ

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Sat Dec 10 00:00:00 EST 2022

Decoding the pathogenesis of Diamond-Blackfan anemia using single-cell RNA-seq.

Cell discovery

Wang B,Wang C,Wan Y,Gao J,Ma Y,Zhang Y,Tong J,Zhang Y,Liu J,Chang L,Xu C,Shen B,Chen Y,Jiang E,Kurita R,Nakamura Y,Lim KC,Engel JD,Zhou J,Cheng T,Zhu X,Zhu P,Shi L

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue May 10 00:00:00 EDT 2022

Effects of the Antidiabetic Drugs Evogliptin and Sitagliptin on the Immune Function of CD26/DPP4 in Th1 Cells.

Biomolecules & therapeutics

Yoon H,Sung JH,Song MJ

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Mon Mar 01 00:00:00 EST 2021

MicroRNA‑21‑5p protects melanocytes via targeting STAT3 and modulating Treg/Teff balance to alleviate vitiligo.

Molecular medicine reports

Huo J,Liu T,Li F,Song X,Hou X

15-0049 was used in Flow cytometry/Cell sorting to suggest that miR-21-5p may protect melanocytes via targeting STAT3 and regulating the regulatory T cell/effector T cell balance, providing a possible treatment for managing vitiligo.

Fri Jan 01 00:00:00 EST 2021

Murlentamab, a Low Fucosylated Anti-Müllerian Hormone Type II Receptor (AMHRII) Antibody, Exhibits Anti-Tumor Activity through Tumor-Associated Macrophage Reprogrammation and T Cell Activation.

Cancers

Prat M,Salon M,Allain T,Dubreuil O,Noël G,Preisser L,Jean B,Cassard L,Lemée F,Tabah-Fish I,Pipy B,Jeannin P,Prost JF,Barret JM,Coste A

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue Apr 13 00:00:00 EDT 2021

Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells.

Molecular therapy. Methods & clinical development

Kierkels GJJ,van Diest E,Hernández-López P,Scheper W,de Bruin ACM,Frijlink E,Aarts-Riemens T,van Dooremalen SFJ,Beringer DX,Oostvogels R,Kramer L,Straetemans T,Uckert W,Sebestyén Z,Kuball J

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Fri Sep 10 00:00:00 EDT 2021

Bispecific T-Cell Engaging Antibodies Against MUC16 Demonstrate Efficacy Against Ovarian Cancer in Monotherapy and in Combination With PD-1 and VEGF Inhibition.

Frontiers in immunology

Yeku OO,Rao TD,Laster I,Kononenko A,Purdon TJ,Wang P,Cui Z,Liu H,Brentjens RJ,Spriggs D

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Thu Oct 21 00:00:00 EDT 2021

Identification of two HLA-A*0201 immunogenic epitopes of lactate dehydrogenase C (LDHC): potential novel targets for cancer immunotherapy.

Cancer immunology, immunotherapy : CII

Thomas R,Shaath H,Naik A,Toor SM,Elkord E,Decock J

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Sun Mar 01 00:00:00 EST 2020

HDAC Inhibitor, CG-745, Enhances the Anti-Cancer Effect of Anti-PD-1 Immune Checkpoint Inhibitor by Modulation of the Immune Microenvironment.

Journal of Cancer

Kim YD,Park SM,Ha HC,Lee AR,Won H,Cha H,Cho S,Cho JM

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

Involvement of natural killer cells in the pathogenesis of endometriosis in patients with pelvic pain.

The Journal of international medical research

He J,Xu Y,Yi M,Gu C,Zhu Y,Hu G

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Wed Jul 01 00:00:00 EDT 2020

Standardized 11-color flow cytometry panel for the functional phenotyping of human T regulatory cells.

Journal of biological methods

Manuszak C,Brainard M,Thrash E,Hodi FS,Severgnini M

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Mon Sep 28 00:00:00 EDT 2020

MicroRNA‑155 inhibits the proliferation of CD8+ T cells via upregulating regulatory T cells in vitiligo.

Molecular medicine reports

Lv M,Li Z,Liu J,Lin F,Zhang Q,Li Z,Wang Y,Wang K,Xu Y

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue Oct 01 00:00:00 EDT 2019

RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.

Cell

Bradley T,Peppa D,Pedroza-Pacheco I,Li D,Cain DW,Henao R,Venkat V,Hora B,Chen Y,Vandergrift NA,Overman RG,Edwards RW,Woods CW,Tomaras GD,Ferrari G,Ginsburg GS,Connors M,Cohen MS,Moody MA,Borrow P,Haynes BF

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Thu Oct 04 00:00:00 EDT 2018

The Effects of High Mobility Group Box-1 Protein on Peripheral Treg/Th17 Balance in Patients with Atherosclerosis.

Acta Cardiologica Sinica

Ding JW,Zhou T,Zheng XX,Wang XA,Tong XH,Luo CY,Zhang ZQ,Yu B

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Sat Sep 01 00:00:00 EDT 2018

Functionalization-dependent effects of cellulose nanofibrils on tolerogenic mechanisms of human dendritic cells.

International journal of nanomedicine

Tomić S,Ilić N,Kokol V,Gruden-Movsesijan A,Mihajlović D,Bekić M,Sofronić-Milosavljević L,Čolić M,Vučević D

15-0049 was used in Flow cytometry/Cell sorting to investigate how differentially functionalised cellulose nanofibrils affect dendritic cell properties, their viability, morphology, differentiation and maturation potential, and the capacity to regulate T cell-mediated immune response.

Mon Dec 31 00:00:00 EST 2018

The Synergistic Effects of the Glutathione Precursor, NAC and First-Line Antibiotics in the Granulomatous Response Against Mycobacterium tuberculosis.

Frontiers in immunology

Teskey G,Cao R,Islamoglu H,Medina A,Prasad C,Prasad R,Sathananthan A,Fraix M,Subbian S,Zhong L,Venketaraman V

15-0049 was used in Immunocytochemistry-immunoflourescence to examine if N-Acetyl Cysteine in combination with antibiotics would be sufficient to completely clear Mycobacterium tuberculosis infection within in vitro granulomas.

Mon Sep 30 00:00:00 EDT 2019

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.

Cell

Horwitz JA,Bar-On Y,Lu CL,Fera D,Lockhart AAK,Lorenzi JCC,Nogueira L,Golijanin J,Scheid JF,Seaman MS,Gazumyan A,Zolla-Pazner S,Nussenzweig MC

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Thu Aug 10 00:00:00 EDT 2017

Blocking the recruitment of naive CD4⁺ T cells reverses immunosuppression in breast cancer.

Cell research

Su S,Liao J,Liu J,Huang D,He C,Chen F,Yang L,Wu W,Chen J,Lin L,Zeng Y,Ouyang N,Cui X,Yao H,Su F,Huang JD,Lieberman J,Liu Q,Song E

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Sat Apr 01 00:00:00 EDT 2017

Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis.

Frontiers in immunology

Hou TY,Chen MR,Chou YC,Kan PC,Tsai YT,Cha TL

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Wed Nov 20 00:00:00 EST 2019

Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.

Journal of leukocyte biology

de Bourayne M,Gallais Y,El Ali Z,Rousseau P,Damiens MH,Cochet C,Filhol O,Chollet-Martin S,Pallardy M,Kerdine-Römer S

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Wed Mar 01 00:00:00 EST 2017

CXCL13-producing TFH cells link immune suppression and adaptive memory in human breast cancer.

JCI insight

Gu-Trantien C,Migliori E,Buisseret L,de Wind A,Brohée S,Garaud S,Noël G,Dang Chi VL,Lodewyckx JN,Naveaux C,Duvillier H,Goriely S,Larsimont D,Willard-Gallo K

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Fri Jun 02 00:00:00 EDT 2017

Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq.

Nature genetics

Reinius B,Mold JE,Ramsköld D,Deng Q,Johnsson P,Michaëlsson J,Frisén J,Sandberg R

15-0049 was used in Flow cytometry/Cell sorting to assess whether, or to what degree, random monoallelic expression of autosomal genes is mitotically inherited or stochastic in somatic cells, particularly in vivo.

Tue Nov 01 00:00:00 EDT 2016

Remarkably low affinity of CD4/peptide-major histocompatibility complex class II protein interactions.

Proceedings of the National Academy of Sciences of the United States of America

Jönsson P,Southcombe JH,Santos AM,Huo J,Fernandes RA,McColl J,Lever M,Evans EJ,Hudson A,Chang VT,Hanke T,Godkin A,Dunne PD,Horrocks MH,Palayret M,Screaton GR,Petersen J,Rossjohn J,Fugger L,Dushek O,Xu XN,Davis SJ,Klenerman D

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue May 17 00:00:00 EDT 2016

Interaction among activated lymphocytes and mesenchymal cells through podoplanin is critical for a high IL-17 secretion.

Arthritis research & therapy

Noack M,Ndongo-Thiam N,Miossec P

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Thu Jun 23 00:00:00 EDT 2016

CD28 family of receptors on T cells in chronic HBV infection: Expression characteristics, clinical significance and correlations with PD-1 blockade.

Molecular medicine reports

Tang ZS,Hao YH,Zhang EJ,Xu CL,Zhou Y,Zheng X,Yang DL

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Mon Aug 01 00:00:00 EDT 2016

Equilibrium of Treg/Th17 cells of peripheral blood in syphilitic patients with sero-resistance.

Experimental and therapeutic medicine

Zhao J,Ma J,Zhang X,Li Q,Yang X

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Wed Jun 01 00:00:00 EDT 2016

Tuning of AKT-pathway by Nef and its blockade by protease inhibitors results in limited recovery in latently HIV infected T-cell line.

Scientific reports

Kumar A,Abbas W,Colin L,Khan KA,Bouchat S,Varin A,Larbi A,Gatot JS,Kabeya K,Vanhulle C,Delacourt N,Pasquereau S,Coquard L,Borch A,König R,Clumeck N,De Wit S,Rohr O,Rouzioux C,Fulop T,Van Lint C,Herbein G

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Thu Apr 14 00:00:00 EDT 2016

Lack of T Cell Response to iPSC-Derived Retinal Pigment Epithelial Cells from HLA Homozygous Donors.

Stem cell reports

Sugita S,Iwasaki Y,Makabe K,Kimura T,Futagami T,Suegami S,Takahashi M

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue Oct 11 00:00:00 EDT 2016

The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.

Journal of immunology (Baltimore, Md. : 1950)

Marquardt N,Ivarsson MA,Blom K,Gonzalez VD,Braun M,Falconer K,Gustafsson R,Fogdell-Hahn A,Sandberg JK,Michaëlsson J

15-0049 was used in Flow cytometry/Cell sorting to study the temporal dynamics and regulation of natural killer cell responses in an acute viral infection.

Thu Oct 01 00:00:00 EDT 2015

Liposomal Glutathione Supplementation Restores TH1 Cytokine Response to Mycobacterium tuberculosis Infection in HIV-Infected Individuals.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research

Ly J,Lagman M,Saing T,Singh MK,Tudela EV,Morris D,Anderson J,Daliva J,Ochoa C,Patel N,Pearce D,Venketaraman V

15-0049 was used in Flow cytometry/Cell sorting to establish a correlation between low levels of glutathione and an increased susceptibility to M. tuberculosis infection.

Sun Nov 01 00:00:00 EDT 2015

Distinct patterns of intratumoral immune cell infiltrates in patients with HPV-associated compared to non-virally induced head and neck squamous cell carcinoma.

Oncoimmunology

Partlová S,Bouček J,Kloudová K,Lukešová E,Zábrodský M,Grega M,Fučíková J,Truxová I,Tachezy R,Špíšek R,Fialová A

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Thu Jan 01 00:00:00 EST 2015

dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Nature communications

Lim S,Kim WJ,Kim YH,Lee S,Koo JH,Lee JA,Yoon H,Kim DH,Park HJ,Kim HM,Lee HG,Yun Kim J,Lee JU,Hun Shin J,Kyun Kim L,Doh J,Kim H,Lee SK,Bothwell ALM,Suh M,Choi JM

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue Sep 15 00:00:00 EDT 2015

Investigating the causes for decreased levels of glutathione in individuals with type II diabetes.

PloS one

Lagman M,Ly J,Saing T,Kaur Singh M,Vera Tudela E,Morris D,Chi PT,Ochoa C,Sathananthan A,Venketaraman V

15-0049 was used in Flow cytometry/Cell sorting to study the mechanisms of reduced levels of glutathione in sufferers of type II diabetes and the effect of this on susceptibility to tuberculosis infection.

Wed Dec 30 00:00:00 EST 2015

The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.

PloS one

Vettermann C,Timblin GA,Lim V,Lai EC,Schlissel MS

15-0049 was used in Flow cytometry/Cell sorting to identify the proximal GT promoter as the first cis-element known to regulate the internal order of Jκ rearrangements.

Tue Jan 26 00:00:00 EST 2016

Immune response to JC virus T antigen in patients with and without colorectal neoplasia.

Gut microbes

Butcher LD,Garcia M,Arnold M,Ueno H,Goel A,Boland CR

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

OMIP-022: Comprehensive assessment of antigen-specific human T-cell functionality and memory.

Cytometry. Part A : the journal of the International Society for Analytical Cytology

Graves AJ,Padilla MG,Hokey DA

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Tue Jul 01 00:00:00 EDT 2014

Human regulatory T cells kill tumor cells through granzyme-dependent cytotoxicity upon retargeting with a bispecific antibody.

Cancer immunology research

Choi BD,Gedeon PC,Herndon JE,Archer GE,Reap EA,Sanchez-Perez L,Mitchell DA,Bigner DD,Sampson JH

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Sun Sep 01 00:00:00 EDT 2013

Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR.

British journal of pharmacology

Vinet J,van Zwam M,Dijkstra IM,Brouwer N,van Weering HR,Watts A,Meijer M,Fokkens MR,Kannan V,Verzijl D,Vischer HF,Smit MJ,Leurs R,Biber K,Boddeke HW

15-0049 was used in Flow cytometry/Cell sorting to study the role of hCCX-CKR in hCXCR3-induced chemotaxis.

Fri Mar 01 00:00:00 EST 2013

Immunosuppressive effect of regulatory T lymphocytes in lung cancer, with special reference to their effects on the induction of autologous tumor-specific cytotoxic T lymphocytes.

Oncology letters

Shigematsu Y,Hanagiri T,Shiota H,Kuroda K,Baba T,Ichiki Y,Yasuda M,Uramoto H,Takenoyama M,Yasumoto K,Tanaka F

15-0049 was used in Flow cytometry/Cell sorting to analyse the distribution of Tregs among tumour-infiltrating lymphocytes, regional lymph node lymphocytes and peripheral blood lymphocytes in patients with lung cancer.

Mon Oct 01 00:00:00 EDT 2012

Increased frequencies of Th22 cells as well as Th17 cells in the peripheral blood of patients with ankylosing spondylitis and rheumatoid arthritis.

PloS one

Zhang L,Li YG,Li YH,Qi L,Liu XG,Yuan CZ,Hu NW,Ma DX,Li ZF,Yang Q,Li W,Li JM

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Fri Jul 27 00:00:00 EDT 2012

Evidence for local dendritic cell activation in pulmonary sarcoidosis.

Respiratory research

Ten Berge B,Kleinjan A,Muskens F,Hammad H,Hoogsteden HC,Hendriks RW,Lambrecht BN,Van den Blink B

15-0049 was used in Flow cytometry/Cell sorting to determine whether, at sites of sarcoidosis, dendritic cells are involved in granuloma formation and maintenance.

Wed Apr 18 00:00:00 EDT 2012

Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients.

Critical care (London, England)

Zhang Y,Li J,Lou J,Zhou Y,Bo L,Zhu J,Zhu K,Wan X,Cai Z,Deng X

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Wed Dec 07 00:00:00 EST 2011

Modulation of CD4+ T lymphocyte lineage outcomes with targeted, nanoparticle-mediated cytokine delivery.

Molecular pharmaceutics

Park J,Gao W,Whiston R,Strom TB,Metcalfe S,Fahmy TM

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Mon Feb 07 00:00:00 EST 2011

Genome-wide identification of human FOXP3 target genes in natural regulatory T cells.

Journal of immunology (Baltimore, Md. : 1950)

Sadlon TJ,Wilkinson BG,Pederson S,Brown CY,Bresatz S,Gargett T,Melville EL,Peng K,D'Andrea RJ,Glonek GG,Goodall GJ,Zola H,Shannon MF,Barry SC

15-0049 was used in Flow cytometry/Cell sorting to demonstrate that in conjunction with CD25, peptidase inhibitor 16 may be a surrogate surface marker for regulatory T-cells.

Thu Jul 15 00:00:00 EDT 2010

Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.

Journal of leukocyte biology

Unsinger J,McDonough JS,Shultz LD,Ferguson TA,Hotchkiss RS

Published figure using CD4 monoclonal antibody (Product # 15-0049-42) in Flow Cytometry

Sat Aug 01 00:00:00 EDT 2009

B cells and monocytes from patients with active multiple sclerosis exhibit increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity.

Retrovirology

Brudek T,Christensen T,Aagaard L,Petersen T,Hansen HJ,Møller-Larsen A

15-0049 was used in Flow cytometry/Cell sorting to study the increased surface expression of both HERV-H Env and HERV-W Env, accompanied by increased seroreactivity, in B cells and monocytes from patients with active multiple sclerosis.

Mon Nov 16 00:00:00 EST 2009

Lateral compartmentalization of T cell receptor versus CD45 by galectin-N-glycan binding and microfilaments coordinate basal and activation signaling.

The Journal of biological chemistry

Chen IJ,Chen HL,Demetriou M

15-0049 was used in Flow cytometry/Cell sorting to investigate the role of the galectin lattice and actin cytoskeleton in controlling microdomain structure and coordinating signal transduction across the plasma membrane.

Fri Nov 30 00:00:00 EST 2007

Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis.

Respiratory research

Mansson A,Adner M,Cardell LO

15-0049 was used in Flow cytometry/Cell sorting to investigate the role of toll-like receptors in human tonsil CD4+ and CD8+ T cells, and their altered expression in patients with recurrent tonsillitis.