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Product Details
PA5-96540
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 276-400 of human SPN (NP_0031141)
Conjugate
Unconjugated
Form
Liquid
Concentration
0.6 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2808342
Product Specific Information
Immunogen sequence: LWRRRQKRRT GALVLSRGGK RNGVVDAWAG PAQVPEEGAV TVTVGGSGGD KGSGFPDGEG SSRRPTLTTF FGRRKSRQGS LAMEELKSGS GPSLKGEEEP LVASEDGAVD APAPDEPEGG DGAAP; Positive Samples: THP-1; Cellular Location: Membrane, Single-pass type I membrane protein
Target Information
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, however, in certain cases also promotes leukocyte aggregation. By interaction with actin-binding proteins ezrin and moesin CD43 plays a regulatory role in remodeling T-cell morphology and regulates cell-cell interactions during lymphocyte traffic. CD43 signaling both enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 causes induction of functionally active tumor suppressor p53 protein, but in case of p53 and ARF deficiency CD43 promotes tumor proliferation and viability. CD43 appears to be an important modulator of leukocyte functions. Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3E8 antigen; B-cell differentiation antigen LP-3; CD43; Galactoglycoprotein; GALGP; GPL115; Leukocyte sialoglycoprotein; Leukosialin; leukosianin; Ly-48; Lymphocyte antigen 48; Sialophorin; sialophorin (gpL115, leukosialin, CD43); sialophorin gpL115; W3/13 antigen
Gene Aliases: A630014B01Rik; CD43; GALGP; GPL115; LSN; Lsn1; Ly-48; Ly48; SPN
UniProt ID: (Human) P16150, (Mouse) P15702
Entrez Gene ID: (Human) 6693, (Rat) 24796, (Mouse) 20737
response to protozoan
negative regulation of type IV hypersensitivity
positive regulation of protein phosphorylation
chemotaxis
immune response
cellular defense response
negative regulation of cell adhesion
establishment or maintenance of cell polarity
signal transduction
cell surface receptor signaling pathway
T cell costimulation
positive regulation of T cell proliferation
negative regulation of T cell proliferation
positive regulation of tumor necrosis factor biosynthetic process
defense response to bacterium
negative thymic T cell selection
regulation of defense response to virus
leukocyte migration
apoptotic signaling pathway
chronic inflammatory response
monocyte activation
regulation of immune response
negative regulation of T cell activation
thymocyte aggregation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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