Product References
Phosphorylation of IGFBP-3 by Casein Kinase 2 Blocks Its Interaction with Hyaluronan, Enabling HA-CD44 Signaling Leading to Increased NSCLC Cell Survival and Cisplatin Resistance.
Cells
Coleman KL,Chiaramonti M,Haddad B,Ranzenberger R,Henning H,Al Khashali H,Ray R,Darweesh B,Guthrie J,Heyl D,Evans HG
MA5-12394 was used in Functional Assay to suggest that blocking CD44 signaling augmented the effects of cisplatin and that IGFBP-3 was more effective at inhibiting HA-CD44 signaling than P-IGFBP-3.
Wed Jan 25 00:00:00 EST 2023
Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells.
Scientific reports
Dorandish S,Williams A,Atali S,Sendo S,Price D,Thompson C,Guthrie J,Heyl D,Evans HG
MA5-12394 was used in Dot blot to study mechanistic insights into regulation of amyloid (A)-β40/42 levels in the media of lung cancer cells using two human non-small cell lung carcinoma cell lines, A549 (p53-positive) and H1299 (p53-null).
Thu May 06 00:00:00 EDT 2021
Regulation of amyloid-β levels by matrix metalloproteinase-2/9 (MMP2/9) in the media of lung cancer cells.
Scientific reports
Dorandish S,Williams A,Atali S,Sendo S,Price D,Thompson C,Guthrie J,Heyl D,Evans HG
MA5-12394 was used in Dot blot to study mechanistic insights into regulation of amyloid (A)-β40/42 levels in the media of lung cancer cells using two human non-small cell lung carcinoma cell lines, A549 (p53-positive) and H1299 (p53-null).
Thu May 06 00:00:00 EDT 2021
Biochemical determinants of the IGFBP-3-hyaluronan interaction.
FEBS open bio
Dorandish S,Devos J,Clegg B,Price D,Muterspaugh R,Guthrie J,Heyl DL,Evans HG
Published figure using CD44 monoclonal antibody (Product # MA5-12394) in Neutralization
Sat Aug 01 00:00:00 EDT 2020
Biochemical determinants of the IGFBP-3-hyaluronan interaction.
FEBS open bio
Dorandish S,Devos J,Clegg B,Price D,Muterspaugh R,Guthrie J,Heyl DL,Evans HG
Published figure using CD44 monoclonal antibody (Product # MA5-12394) in Neutralization
Sat Aug 01 00:00:00 EDT 2020
IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner.
Scientific reports
Price D,Muterspaugh R,Clegg B,Williams A,Stephens A,Guthrie J,Heyl D,Evans HG
MA5-12394 was used in MTT reduction assay to show that IGFBP-3 or its peptide blocks hyaluronan-CD44 signaling via a mechanism that depends on both p53 and acetylcholinesterase.
Thu Mar 19 00:00:00 EDT 2020
IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner.
Scientific reports
Price D,Muterspaugh R,Clegg B,Williams A,Stephens A,Guthrie J,Heyl D,Evans HG
MA5-12394 was used in MTT reduction assay to show that IGFBP-3 or its peptide blocks hyaluronan-CD44 signaling via a mechanism that depends on both p53 and acetylcholinesterase.
Thu Mar 19 00:00:00 EDT 2020
Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence.
Biomaterials
Ferreira SA,Faull PA,Seymour AJ,Yu TTL,Loaiza S,Auner HW,Snijders AP,Gentleman E
MA5-12394 was used in Inhibition experiments to study the contributions of 3D hydrogel matrix- and non-matrix-mediated cues in directing mesenchymal stem cell response.
Sat Sep 01 00:00:00 EDT 2018
Bi-directional cell-pericellular matrix interactions direct stem cell fate.
Nature communications
Ferreira SA,Motwani MS,Faull PA,Seymour AJ,Yu TTL,Enayati M,Taheem DK,Salzlechner C,Haghighi T,Kania EM,Oommen OP,Ahmed T,Loaiza S,Parzych K,Dazzi F,Varghese OP,Festy F,Grigoriadis AE,Auner HW,Snijders AP,Bozec L,Gentleman E
MA5-12394 was used for blocking to show that human bone marrow stromal cells encapsulated within hyaluronic acid-based hydrogels modify their surroundings by synthesising, secreting and arranging proteins pericellularly or by degrading the hydrogel.
Wed Oct 03 00:00:00 EDT 2018
Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.
Oncogene
Guo JY,Hsu HS,Tyan SW,Li FY,Shew JY,Lee WH,Chen JY
Published figure using CD44 monoclonal antibody (Product # MA5-12394) in Western Blot
Thu Apr 27 00:00:00 EDT 2017
Serglycin in tumor microenvironment promotes non-small cell lung cancer aggressiveness in a CD44-dependent manner.
Oncogene
Guo JY,Hsu HS,Tyan SW,Li FY,Shew JY,Lee WH,Chen JY
Published figure using CD44 monoclonal antibody (Product # MA5-12394) in Western Blot
Thu Apr 27 00:00:00 EDT 2017
Soluble CD83 Inhibits T Cell Activation by Binding to the TLR4/MD-2 Complex on CD14+ Monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Horvatinovich JM,Grogan EW,Norris M,Steinkasserer A,Lemos H,Mellor AL,Tcherepanova IY,Nicolette CA,DeBenedette MA
MA512394 was used in blocking or activating experiment to implicate myeloid differentiation factor-2 as the high-affinity soluble CD83 binding partner
Wed Mar 15 00:00:00 EDT 2017
Breast cancer cells respond differentially to modulation of TGFβ2 signaling after exposure to chemotherapy or hypoxia.
Cancer research
O'Brien SK,Chen L,Zhong W,Armellino D,Yu J,Loreth C,Follettie M,Damelin M
MA5-12394 was used in Inhibition experiments to study the emergence of distinct resistant tumour cell populations as a consequence of prior therapeutic intervention or microenvironmental cues, and their implications for the responsiveness of recurring tumours to therapy.
Sun Nov 01 00:00:00 EDT 2015
CD44 mediated hyaluronan adhesion of Toxoplasma gondii-infected leukocytes.
Parasitology international
Hayashi T,Unno A,Baba M,Ohno T,Kitoh K,Takashima Y
MA5-12394 was used in blocking or activating experiment to study the role of elevated CD44 expression in the mechanism by which Toxoplasma gondii infection promotes increased leukocyte hyaluron adhesion
Tue Apr 01 00:00:00 EDT 2014
Hyaluronan initiates chondrogenesis mainly via CD44 in human adipose-derived stem cells.
Journal of applied physiology (Bethesda, Md. : 1985)
Wu SC,Chen CH,Chang JK,Fu YC,Wang CK,Eswaramoorthy R,Lin YS,Wang YH,Lin SY,Wang GJ,Ho ML
MA5-12394 was used in blocking or activating experiment to study the role of the hyaluron-CD44 interaction in triggering chondrogenesis in human adipose tissue -derived stem cells
Sat Jun 01 00:00:00 EDT 2013
Role of hyaluronan and hyaluronan-binding proteins in human asthma.
The Journal of allergy and clinical immunology
Liang J,Jiang D,Jung Y,Xie T,Ingram J,Church T,Degan S,Leonard M,Kraft M,Noble PW
MA5-12394 was used in Neutralization experiments to investigate the role of hyaluronan and hyaluronan binding proteins in human asthma.
Mon Aug 01 00:00:00 EDT 2011
Inhibition of CD44 N- and O-linked glycosylation decreases endometrial cell lines attachment to peritoneal mesothelial cells.
Fertility and sterility
Rodgers AK,Nair A,Binkley PA,Tekmal R,Schenken RS
MA5-12394 was used in flow cytometry to study the role of N- and O-linked glycosylation in the attachment of endothelial cells to peritoneal mesothelial cells.
Tue Feb 01 00:00:00 EST 2011
Differentiation of human mesenchymal stem cells: the potential mechanism for estrogen-induced preferential osteoblast versus adipocyte differentiation.
The American journal of the medical sciences
Zhao JW,Gao ZL,Mei H,Li YL,Wang Y
MA5-12394 was used in flow cytometry to investigate the regulatory role of estrogen signaling pathways in the differentiation of mesenchymal stem cells in vitro
Wed Jun 01 00:00:00 EDT 2011
Adhesion-mediated self-renewal abilities of Ph+ blastoma cells.
Biochemical and biophysical research communications
Funayama K,Saito-Kurimoto Y,Ebihara Y,Shimane M,Nomura H,Tsuji K,Asano S
MA5-12394 was used in blocking or activating experiment to investigate the effect of cell adhesion on leukemic stem cell self-renewal
Fri May 28 00:00:00 EDT 2010
High molecular weight hyaluronic acid inhibits IL-6-induced MMP production from human chondrocytes by up-regulating the ERK inhibitor, MKP-1.
Biochemical and biophysical research communications
Hashizume M,Mihara M
MA5-12394 was used in blocking or activating experiment to study the effect high molecular weight hyaluronic acid on MMP production from human chondrocytes and its mechanism
Fri Dec 10 00:00:00 EST 2010
Inhibition of human pancreatic cell line MIA PaCa2 proliferation by HA-But, a hyaluronic butyric ester: a preliminary report.
Pancreas
Pellizzaro C,Speranza A,Zorzet S,Crucil I,Sava G,Scarlata I,Cantoni S,Fedeli M,Coradini D
MA5-12394 was used in flow cytometry to examine the effect of hyaluronic butyric ester HA-But on the proliferation of human pancreatic cell line MIA PaCa2
Thu May 01 00:00:00 EDT 2008
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis.
Osteoarthritis and cartilage
Wang CT,Lin YT,Chiang BL,Lin YH,Hou SM
MA5-12394 was used in blocking or activating experiment to examine the therapeutic effect of high molecular weight hyaluronic acid in patients with early osteoarthritis
Fri Dec 01 00:00:00 EST 2006
Suppressive effects of hyaluronan on MMP-1 and RANTES production from chondrocytes.
Rheumatology international
Tanaka M,Masuko-Hongo K,Kato T,Nishioka K,Nakamura H
MA5-12394 was used in blocking or activating experiment to study the effects of hyaluronan on MMP-1 and RANTES production from chondrocytes
Sun Jan 01 00:00:00 EST 2006
Mesenchymal stem cells transduced by PLEGFP-N1 retroviral vector maintain their biological features and differentiation.
Chinese medical journal
He X,Li YL,Wang XR,Guo X,Niu Y
MA5-12394 was used in flow cytometry to evaluate the utility of enhanced green fluorescent protein transduction in human mesenchymal stem cells
Thu Oct 20 00:00:00 EDT 2005
Inhibition of hepatocellular carcinomas in vitro and hepatic metastases in vivo in mice by the histone deacetylase inhibitor HA-But.
Clinical cancer research : an official journal of the American Association for Cancer Research
Coradini D,Zorzet S,Rossin R,Scarlata I,Pellizzaro C,Turrin C,Bello M,Cantoni S,Speranza A,Sava G,Mazzi U,Perbellini A
MA5-12394 was used in flow cytometry to investigate the effect of histone deacetylase inhibitor on intrahepatic tumor lesions
Thu Jul 15 00:00:00 EDT 2004
Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: a preclinical study.
Investigational new drugs
Coradini D,Pellizzaro C,Abolafio G,Bosco M,Scarlata I,Cantoni S,Stucchi L,Zorzet S,Turrin C,Sava G,Perbellini A,Daidone MG
MA5-12394 was used in flow cytometry to investigate the therapeutic effect of hyaluronic-acid butyric esters in lung carcinomas
Sun Aug 01 00:00:00 EDT 2004
Hyaluronic acid or TNF-alpha plus fibronectin triggers granulocyte macrophage-colony-stimulating factor mRNA stabilization in eosinophils yet engages differential intracellular pathways and mRNA binding proteins.
Journal of immunology (Baltimore, Md. : 1950)
Esnault S,Malter JS
MA5-12394 was used in western blot to investigate the effect of tumor necrosis factor alpha and hyaluronic acid on the long-term eosinophil survival and its mechanism
Mon Dec 15 00:00:00 EST 2003
