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产品信息
PA5-79525
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Not Applicable
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1 (1121-1134aa SNQKRELAIQISKD).
偶联物
Unconjugated
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 4mg trehalose
内含物
no preservative
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2746641
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
靶标信息
Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: CD49 antigen-like family member A; CD49a; integrin alpha 1; Integrin alpha-1; integrin, alpha 1; Laminin and collagen receptor; very late activation protein 1; VLA-1
基因别名: CD49A; E130012M19Rik; ITGA1; VLA1
UniProt ID: (Human) P56199, (Rat) P18614, (Mouse) Q3V3R4
Entrez Gene ID: (Human) 3672, (Rat) 25118, (Mouse) 109700
activation of MAPK activity
muscle contraction
cell-matrix adhesion
integrin-mediated signaling pathway
negative regulation of cell proliferation
extracellular matrix organization
neutrophil chemotaxis
positive regulation of phosphoprotein phosphatase activity
negative regulation of epidermal growth factor receptor signaling pathway
vasodilation
positive regulation of neuron apoptotic process
cellular extravasation
neuron projection morphogenesis
cell adhesion
cell chemotaxis
