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CD59 Antibody (MA5-36049) in Flow
Flow Cytometry analysis of CD59 in BABL/c bone marrow erythroid cells. Cells were stained with CD59 Recombinant Monoclonal Antibody (Product # MA5-36049), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of erythroid cells.
产品信息
MA5-36049
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
108
抗原
Recombinant Mouse CD59a/Protectin Protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2866661
靶标信息
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD59; CD59 antigen; CD59A glycoprotein; CD59B glycoprotein; MAC-inhibitory protein; MAC-IP; MACIF; Membrane attack complex inhibition factor; Protectin
基因别名: AA987121; Cd59; Cd59a; Cd59b; protectin
UniProt ID: (Mouse) O55186, (Mouse) P58019
Entrez Gene ID: (Mouse) 12509, (Mouse) 333883
negative regulation of activation of membrane attack complex
cell surface receptor signaling pathway
negative regulation of angiogenesis
negative regulation of vascular endothelial growth factor receptor signaling pathway
negative regulation of complement activation
negative regulation of fibroblast growth factor production
positive regulation of T cell proliferation
negative regulation of apoptotic process
negative regulation of cytolysis
