Invitrogen

CD6 Polyclonal Antibody

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CD6 Antibody (PA5-99430) in WB

Western blot analysis of CD6 extracts from COLO205 cells (heat-shock treatment). Samples were incubated with CD6 polyclonal antibody (Product # PA5-99430) using a dilution of 1:1,000. Observed bands: 60 kDa.

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产品信息

PA5-99430

应用

建议稀释比

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免疫印迹 (WB)

1:500-1:2,000

免疫细胞化学 (ICC/IF)

1:100-1:500

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthesized peptide derived from human CD6(Accession P30203), corresponding to amino acid residues G250-K300.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

RRID

AB_2818363

产品详细信息

Antibody detects endogenous levels of total CD6.

靶标信息

CD6, also known as T12, is a member of the scavenger receptor superfamily found on T and B cell subsets, thymocytes, and acute lymphocytic leukemia cells (ALL). CD6 interacts with its ligand CD166/ALCAM (activated leukocyte cell adhesion molecule) and serves as a coreceptor for T cell activation and stabilizer of the immunological synapse. CD6-ALCAM mediated cell adhesion is also important for T cell proliferation. CD6 may exert some its functions via association with CD5, probably by fine-tuning CD5 signaling. Ligation of CD6 has antiapoptotic role in chronic lymphocytic leukemia B cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。