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Invitrogen
CD62L (L-Selectin) Monoclonal Antibody (SK11), FITC, eBioscience™
图: 1 / 1
CD62L (L-Selectin) Antibody (11-0625-42) in Flow
Staining of normal human peripheral blood cells with Anti-Human CD4 APC (Product # 17-0048-42) and Mouse IgG2a K Isotype Control FITC (Product # 11-4724-42) (left) or Anti-Human/NHP CD62L (L-selectin) FITC (right). Cells in the lymphocyte gate were used for analysis.
产品信息
11-0625-42
产品规格
种属反应
Baboon,
Chimpanzee,
Cynomolgus monkey,
Human,
Non-human primate,
Rhesus monkey
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
SK11
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
5 µL/Test
纯化类型
Affinity chromatography
保存液
PBS, pH 7.2, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_10597901
产品详细信息
Description: This SK11 monoclonal antibody reacts with human and non-human primate CD62L (also known as L-selectin and LECAM). CD62L is expressed on neutrophils, monocytes, and subsets of T, B, and NK cells, as well as endothelial cells. This cell surface adhesion molecule binds glycolsylated, fucosylated and sulfated sialylated glycoproteins, including CD34, glycam-1, and MadCAM-1. These interactions mediate rolling of lymphocytes on activated endothelium at the sites of inflammation and homing of cells to the high endothelial venules (HEV) of peripheral lymphoid tissues.
The SK11 antibody has been reported to recognize chimpanzee, rhesus, cynomolgus monkey, olive baboon, and pigtailed macaque as well as pig.
Applications Reported: This SK11 antibody has been reported for use in flow cytometric analysis.
Applications Tested: This SK11 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.
Filtration: 0.2 µm post-manufacturing filtered.
靶标信息
The human CD62L is a 74-95 kDa glycoprotein member of the selectin family of adhesion receptors. L-Selectin is comprised of an aminoterminal C-type lectin binding domain, an epidermal growth factor-like domain, two short consensus repeat (SCR) sequences homologous to those found in complement binding proteins, a short spacer region, a transmembrane region and a short cytoplasmic region. Human CD62L (L-Selectin) is constitutively expressed on all classes of leukocytes including lymphocytes (except a substantial population of memory T cells), monocytes and polymorphonuclear cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD62 antigen-like family member L; CD62L; gp90-MEL; hLHRc; L-selectin; LAM-1; LECAM1; Leu-8; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; Lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor; selectin E (endothelial adhesion molecule 1); selectin L (lymphocyte adhesion molecule 1); TQ1
基因别名: CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; SELE; SELL; TQ1
UniProt ID: (Rhesus monkey) Q95198, (Human) P14151, (Chimpanzee) Q95237
Entrez Gene ID: (Cynomolgus monkey) 102142895, (Rhesus monkey) 701419, (Human) 6402, (Chimpanzee) 450191
